Chikungunya Virus Infection Results in Higher and Persistent Viral Replication in Aged Rhesus Macaques Due to Defects in Anti-Viral Immunity

• Ilhem Messaoudi ,

  * E-mail: messaoud@ucr.edu (IM); streblow@ohsu.edu (DNS)

  Current address: University of California-Riverside, Riverside, California, United States of America

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• Jennifer Vomaske,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Thomas Totonchy,

  Affiliation Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America

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• Craig N. Kreklywich,

  Affiliation Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America

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• Kristen Haberthur,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• Laura Springgay,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• James D. Brien,

  Affiliation Departments of Molecular Microbiology, Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Michael S. Diamond,

  Affiliation Departments of Molecular Microbiology, Medicine, Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America

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• Victor R. DeFilippis,

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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• Daniel N. Streblow

  * E-mail: messaoud@ucr.edu (IM); streblow@ohsu.edu (DNS)

  Affiliations Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, United States of America, Molecular Microbiology and Immunology, Oregon Health and Science University, Portland, Oregon, United States of America, Division of Pathobiology and Immunology, Oregon National Primate Research Center, Beaverton, Oregon, United States of America

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