Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

Juan P. Rigalli; Virginia G. Perdomo; Marcelo G. Luquita; Silvina S. M. Villanueva; Agostina Arias; Dirk Theile; Johanna Weiss; Aldo D. Mottino; María L. Ruiz; Viviana A. Catania

doi:10.1371/journal.pntd.0001951

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Open Access

Peer-reviewed

Research Article

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

Juan P. Rigalli,

Affiliations Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina, Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
⨯
Virginia G. Perdomo,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
Marcelo G. Luquita,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
Silvina S. M. Villanueva,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
Agostina Arias,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
Dirk Theile,

Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
⨯
Johanna Weiss,

Affiliation Department of Clinical Pharmacology and Pharmacoepidemiology, University of Heidelberg, Heidelberg, Germany
⨯
Aldo D. Mottino,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
María L. Ruiz,

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯
Viviana A. Catania

* E-mail: vcatania@fbioyf.unr.edu.ar

Affiliation Institute of Experimental Physiology (CONICET), School of Biochemical and Pharmaceutical Sciences (UNR), Rosario, Argentina
⨯

Regulation of Biotransformation Systems and ABC Transporters by Benznidazole in HepG2 Cells: Involvement of Pregnane X-Receptor

Juan P. Rigalli,
Virginia G. Perdomo,
Marcelo G. Luquita,
Silvina S. M. Villanueva,
Agostina Arias,
Dirk Theile,
Johanna Weiss,
Aldo D. Mottino,
María L. Ruiz,
Viviana A. Catania

Published: December 13, 2012
https://doi.org/10.1371/journal.pntd.0001951

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