T-Cell Memory Responses Elicited by Yellow Fever Vaccine are Targeted to Overlapping Epitopes Containing Multiple HLA-I and -II Binding Motifs

Andréa Barbosa de Melo; Eduardo J. M. Nascimento; Ulisses Braga-Neto; Rafael Dhalia; Ana Maria Silva; Mathias Oelke; Jonathan P. Schneck; John Sidney; Alessandro Sette; Silvia M. L. Montenegro; Ernesto T. A. Marques

doi:10.1371/journal.pntd.0001938

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Open Access

Peer-reviewed

Research Article

T-Cell Memory Responses Elicited by Yellow Fever Vaccine are Targeted to Overlapping Epitopes Containing Multiple HLA-I and -II Binding Motifs

Andréa Barbosa de Melo,

Affiliation Virology and Experimental Therapeutics Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil
⨯
Eduardo J. M. Nascimento,

Affiliation Center for Vaccine Research, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯
Ulisses Braga-Neto,

Affiliation Department of Electrical and Computer Engineering, Texas A&M University, College Station, Texas, United States of America
⨯
Rafael Dhalia,

Affiliation Virology and Experimental Therapeutics Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil
⨯
Ana Maria Silva,

Affiliation Virology and Experimental Therapeutics Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil
⨯
Mathias Oelke,

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Jonathan P. Schneck,

Affiliation Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
John Sidney,

Affiliation La Jolla Institute for Allergy and Immunology, Vaccine Discovery, La Jolla, California, United States of America
⨯
Alessandro Sette,

Affiliation La Jolla Institute for Allergy and Immunology, Vaccine Discovery, La Jolla, California, United States of America
⨯
Silvia M. L. Montenegro,

Affiliation Department of Immunology, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil
⨯
Ernesto T. A. Marques

* E-mail: marques@pitt.edu

Affiliations Virology and Experimental Therapeutics Laboratory, Aggeu Magalhães Research Center, Fiocruz, Recife, Pernambuco, Brazil, Center for Vaccine Research, Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America
⨯

T-Cell Memory Responses Elicited by Yellow Fever Vaccine are Targeted to Overlapping Epitopes Containing Multiple HLA-I and -II Binding Motifs

Andréa Barbosa de Melo,
Eduardo J. M. Nascimento,
Ulisses Braga-Neto,
Rafael Dhalia,
Ana Maria Silva,
Mathias Oelke,
Jonathan P. Schneck,
John Sidney,
Alessandro Sette,
Silvia M. L. Montenegro

Published: January 31, 2013
https://doi.org/10.1371/journal.pntd.0001938

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