Rickettsiae Induce Microvascular Hyperpermeability via Phosphorylation of VE-Cadherins: Evidence from Atomic Force Microscopy and Biochemical Studies

Bin Gong; Liang Ma; Yan Liu; Qinyu Gong; Thomas Shelite; Donald Bouyer; Paul J. Boor; Yong Sun Lee; Andres Oberhauser

doi:10.1371/journal.pntd.0001699

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Open Access

Peer-reviewed

Research Article

Rickettsiae Induce Microvascular Hyperpermeability via Phosphorylation of VE-Cadherins: Evidence from Atomic Force Microscopy and Biochemical Studies

Bin Gong ,

* E-mail: bigong@utmb.edu

Affiliations Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Liang Ma,

Affiliation Department of Neurosciences and Cell Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Yan Liu,

Affiliation Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Qinyu Gong,

Affiliation Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Thomas Shelite,

Affiliation Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Donald Bouyer,

Affiliations Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Center for Biodefense and Emerging Infectious Diseases, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Paul J. Boor,

Affiliation Department of Pathology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Yong Sun Lee,

Affiliation Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯
Andres Oberhauser

Affiliations Department of Neurosciences and Cell Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Department of Biochemistry and Molecular Biology, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America, Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch at Galveston, Galveston, Texas, United States of America
⨯

Rickettsiae Induce Microvascular Hyperpermeability via Phosphorylation of VE-Cadherins: Evidence from Atomic Force Microscopy and Biochemical Studies

Bin Gong,
Liang Ma,
Yan Liu,
Qinyu Gong,
Thomas Shelite,
Donald Bouyer,
Paul J. Boor,
Yong Sun Lee,
Andres Oberhauser

Published: June 12, 2012
https://doi.org/10.1371/journal.pntd.0001699

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Phosphorylation
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Vascular permeability
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Endothelial cells
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Permeability
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Atomic force microscopy
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Tyrosine
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Immunoprecipitation
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Rickettsia rickettsii
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