An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

Jair L. Siqueira-Neto; Seunghyun Moon; Jiyeon Jang; Gyongseon Yang; Changbok Lee; Hong Kee Moon; Eric Chatelain; Auguste Genovesio; Jonathan Cechetto; Lucio H. Freitas-Junior

doi:10.1371/journal.pntd.0001671

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Open Access

Peer-reviewed

Research Article

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

Jair L. Siqueira-Neto ,

Contributed equally to this work with: Jair L. Siqueira-Neto, Seunghyun Moon, Jiyeon Jang

Affiliation Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Seunghyun Moon ,

Contributed equally to this work with: Jair L. Siqueira-Neto, Seunghyun Moon, Jiyeon Jang

Affiliation Image Mining Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Jiyeon Jang ,

Contributed equally to this work with: Jair L. Siqueira-Neto, Seunghyun Moon, Jiyeon Jang

Affiliation Screening Technology & Pharmacology Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Gyongseon Yang,

Affiliation Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Changbok Lee,

Affiliation Image Mining Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Hong Kee Moon,

Affiliation Image Mining Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Eric Chatelain,

Affiliation Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland
⨯
Auguste Genovesio ,

* E-mail: freitasjunior@ip-korea.org (LHFJ); cechetto@ip-korea.org (JC); auguste@broad.mit.edu (AG)

Current address: Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America

Affiliation Image Mining Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Jonathan Cechetto ,

* E-mail: freitasjunior@ip-korea.org (LHFJ); cechetto@ip-korea.org (JC); auguste@broad.mit.edu (AG)

Affiliation Screening Technology & Pharmacology Group, Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯
Lucio H. Freitas-Junior

* E-mail: freitasjunior@ip-korea.org (LHFJ); cechetto@ip-korea.org (JC); auguste@broad.mit.edu (AG)

Affiliation Center for Neglected Diseases Drug Discovery (CND3), Institut Pasteur Korea, Seongnam-si, Gyeonggi-do, South Korea
⨯

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

Jair L. Siqueira-Neto,
Seunghyun Moon,
Jiyeon Jang,
Gyongseon Yang,
Changbok Lee,
Hong Kee Moon,
Eric Chatelain,
Auguste Genovesio,
Jonathan Cechetto,
Lucio H. Freitas-Junior

Published: June 12, 2012
https://doi.org/10.1371/journal.pntd.0001671

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