Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing

Louisa A. Messenger; Martin S. Llewellyn; Tapan Bhattacharyya; Oscar Franzén; Michael D. Lewis; Juan David Ramírez; Hernan J. Carrasco; Björn Andersson; Michael A. Miles

doi:10.1371/journal.pntd.0001584

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Peer-reviewed

Research Article

Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing

Louisa A. Messenger ,

* E-mail: louisa.messenger@lshtm.ac.uk

Affiliation Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Martin S. Llewellyn,

Affiliation Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Tapan Bhattacharyya,

Affiliation Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Oscar Franzén,

Affiliation Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Michael D. Lewis,

Affiliation Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯
Juan David Ramírez,

Affiliation Centro de Investigaciones en Microbiología y Parasitología Tropical, CIMPAT, Universidad de los Andes, Bogotá, Colombia
⨯
Hernan J. Carrasco,

Affiliation Instituto de Medicina Tropical, Facultad de Medicina, Universidad Central de Venezuela, Los Chaguaramos, Caracas, Venezuela
⨯
Björn Andersson,

Affiliation Science for Life Laboratory, Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden
⨯
Michael A. Miles

Affiliation Department of Pathogen Molecular Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
⨯

Multiple Mitochondrial Introgression Events and Heteroplasmy in Trypanosoma cruzi Revealed by Maxicircle MLST and Next Generation Sequencing

Louisa A. Messenger,
Martin S. Llewellyn,
Tapan Bhattacharyya,
Oscar Franzén,
Michael D. Lewis,
Juan David Ramírez,
Hernan J. Carrasco,
Björn Andersson,
Michael A. Miles

Published: April 10, 2012
https://doi.org/10.1371/journal.pntd.0001584

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Trypanosoma cruzi
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Genomics
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Mitochondria
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Single nucleotide polymorphisms
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