The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

Rosario Diaz-Gonzalez; F. Matthew Kuhlmann; Cristina Galan-Rodriguez; Luciana Madeira da Silva; Manuel Saldivia; Caitlin E. Karver; Ana Rodriguez; Stephen M. Beverley; Miguel Navarro; Michael P. Pollastri

doi:10.1371/journal.pntd.0001297

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Peer-reviewed

Research Article

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

Rosario Diaz-Gonzalez,

Affiliation Instituto de Parasitología y Biomedicina “López-Neyra” Consejo Superior de Investigaciones Cientificas, Granada, Spain
⨯
F. Matthew Kuhlmann,

Affiliation Department of Medicine-Division of Infectious Diseases, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Cristina Galan-Rodriguez,

Affiliation Division of Medical Parasitology, Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
⨯
Luciana Madeira da Silva,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Manuel Saldivia,

Affiliation Instituto de Parasitología y Biomedicina “López-Neyra” Consejo Superior de Investigaciones Cientificas, Granada, Spain
⨯
Caitlin E. Karver,

Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America
⨯
Ana Rodriguez,

Affiliation Division of Medical Parasitology, Department of Microbiology, New York University School of Medicine, New York, New York, United States of America
⨯
Stephen M. Beverley,

Affiliation Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America
⨯
Miguel Navarro,

Affiliation Instituto de Parasitología y Biomedicina “López-Neyra” Consejo Superior de Investigaciones Cientificas, Granada, Spain
⨯
Michael P. Pollastri

* E-mail: M.Pollastri@neu.edu

Affiliation Department of Chemistry and Chemical Biology, Northeastern University, Boston, Massachusetts, United States of America
⨯

The Susceptibility of Trypanosomatid Pathogens to PI3/mTOR Kinase Inhibitors Affords a New Opportunity for Drug Repurposing

Rosario Diaz-Gonzalez,
F. Matthew Kuhlmann,
Cristina Galan-Rodriguez,
Luciana Madeira da Silva,
Manuel Saldivia,
Caitlin E. Karver,
Ana Rodriguez,
Stephen M. Beverley,
Miguel Navarro,
Michael P. Pollastri

Published: August 23, 2011
https://doi.org/10.1371/journal.pntd.0001297

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