A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized Trial

Anna P. Durbin; Stephen S. Whitehead; Donna Shaffer; Dan Elwood; Kimberli Wanionek; Bhavin Thumar; Joseph E. Blaney; Brian R. Murphy; Alexander C. Schmidt

doi:10.1371/journal.pntd.0001267

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Open Access

Peer-reviewed

Research Article

A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized Trial

Anna P. Durbin ,

* E-mail: adurbin@jhsph.edu

Affiliation Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Stephen S. Whitehead,

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Donna Shaffer,

Affiliation Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Dan Elwood,

Affiliation Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Kimberli Wanionek,

Affiliation Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Bhavin Thumar,

Affiliation Center for Immunization Research, Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, United States of America
⨯
Joseph E. Blaney,

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Brian R. Murphy,

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Alexander C. Schmidt

Affiliation Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯

A Single Dose of the DENV-1 Candidate Vaccine rDEN1Δ30 Is Strongly Immunogenic and Induces Resistance to a Second Dose in a Randomized Trial

Anna P. Durbin,
Stephen S. Whitehead,
Donna Shaffer,
Dan Elwood,
Kimberli Wanionek,
Bhavin Thumar,
Joseph E. Blaney,
Brian R. Murphy,
Alexander C. Schmidt

Published: August 2, 2011
https://doi.org/10.1371/journal.pntd.0001267

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