High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

Roderick G. Walker; Graeme Thomson; Kirk Malone; Matthew W. Nowicki; Elaine Brown; David G. Blake; Nicholas J. Turner; Malcolm D. Walkinshaw; Karen M. Grant; Jeremy C. Mottram

doi:10.1371/journal.pntd.0001033

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Peer-reviewed

Research Article

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

Roderick G. Walker,

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
Graeme Thomson,

Affiliation Cyclacel Ltd., Dundee, Dundee, United Kingdom
⨯
Kirk Malone,

Affiliation Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
⨯
Matthew W. Nowicki,

Affiliation Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Elaine Brown,

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯
David G. Blake,

Affiliation Cyclacel Ltd., Dundee, Dundee, United Kingdom
⨯
Nicholas J. Turner,

Affiliation Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, United Kingdom
⨯
Malcolm D. Walkinshaw,

Affiliation Institute of Structural and Molecular Biology, The University of Edinburgh, Edinburgh, United Kingdom
⨯
Karen M. Grant,

Affiliation School of Health & Medicine, Division of Medicine, Lancaster University, Lancaster, United Kingdom
⨯
Jeremy C. Mottram

* E-mail: j.mottram@udcf.gla.ac.uk

Affiliation Wellcome Trust Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom
⨯

High Throughput Screens Yield Small Molecule Inhibitors of Leishmania CRK3:CYC6 Cyclin-Dependent Kinase

Roderick G. Walker,
Graeme Thomson,
Kirk Malone,
Matthew W. Nowicki,
Elaine Brown,
David G. Blake,
Nicholas J. Turner,
Malcolm D. Walkinshaw,
Karen M. Grant,
Jeremy C. Mottram

Published: April 5, 2011
https://doi.org/10.1371/journal.pntd.0001033

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Leishmania
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Protein kinases
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Parasitic cell cycles
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