Identification of Potent Chemotypes Targeting Leishmania major Using a High-Throughput, Low-Stringency, Computationally Enhanced, Small Molecule Screen

• Elizabeth R. Sharlow,

  Affiliations University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• David Close,

  Affiliation University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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• Tongying Shun,

  Affiliation University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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• Stephanie Leimgruber,

  Affiliation University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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• Robyn Reed,

  Affiliation University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America

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• Gabriela Mustata,

  Affiliation Department of Computational Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Peter Wipf,

  Affiliations University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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• Jacob Johnson,

  Affiliation Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Michael O'Neil,

  Affiliation Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Max Grögl,

  Affiliation Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• Alan J. Magill,

  Affiliation Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America

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• John S. Lazo

  * E-mail: lazo@pitt.edu

  Affiliations University of Pittsburgh Drug Discovery Institute and the Pittsburgh Molecular Library Screening Center, Pittsburgh, Pennsylvania, United States of America, Departments of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America

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