The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target

Bo Wu; Jacopo Novelli; Jeremy Foster; Romualdas Vaisvila; Leslie Conway; Jessica Ingram; Mehul Ganatra; Anita U. Rao; Iqbal Hamza; Barton Slatko

doi:10.1371/journal.pntd.0000475

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Open Access

Peer-reviewed

Research Article

The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target

Bo Wu,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Jacopo Novelli,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Jeremy Foster,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Romualdas Vaisvila,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Leslie Conway,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Jessica Ingram,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Mehul Ganatra,

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯
Anita U. Rao,

Affiliation Department of Animal and Avian Sciences and Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
⨯
Iqbal Hamza,

Affiliation Department of Animal and Avian Sciences and Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, Maryland, United States of America
⨯
Barton Slatko

* E-mail: slatko@neb.com

Affiliation Division of Molecular Parasitology, New England Biolabs, Ipswich, Massachusetts, United States of America
⨯

The Heme Biosynthetic Pathway of the Obligate Wolbachia Endosymbiont of Brugia malayi as a Potential Anti-filarial Drug Target

Bo Wu,
Jacopo Novelli,
Jeremy Foster,
Romualdas Vaisvila,
Leslie Conway,
Jessica Ingram,
Mehul Ganatra,
Anita U. Rao,
Iqbal Hamza,
Barton Slatko

Published: July 14, 2009
https://doi.org/10.1371/journal.pntd.0000475

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Wolbachia
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Heme
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Brugia malayi
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Phylogenetic analysis
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Enzyme assays
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Biosynthesis
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Drug discovery
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Caenorhabditis elegans
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