Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design

Asif M. Khan; Olivo Miotto; Eduardo J. M. Nascimento; K. N. Srinivasan; A. T. Heiny; Guang Lan Zhang; E. T. Marques; Tin Wee Tan; Vladimir Brusic; Jerome Salmon; J. Thomas August

doi:10.1371/journal.pntd.0000272

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Open Access

Peer-reviewed

Research Article

Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design

Asif M. Khan,

Affiliation Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯
Olivo Miotto,

Affiliations Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Institute of Systems Science, National University of Singapore, Singapore
⨯
Eduardo J. M. Nascimento,

Affiliation Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
K. N. Srinivasan,

Affiliations Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Product Evaluation and Registration Division, Centre for Drug Administration, Health Sciences Authority, Singapore
⨯
A. T. Heiny,

Affiliation Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯
Guang Lan Zhang,

Affiliation Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
E. T. Marques,

Affiliations Department of Medicine, Division of Infectious Diseases, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
Tin Wee Tan,

Affiliation Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore
⨯
Vladimir Brusic,

Affiliation Cancer Vaccine Center, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Jerome Salmon,

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯
J. Thomas August

* E-mail: taugust@jhmi.edu

Affiliation Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America
⨯

Conservation and Variability of Dengue Virus Proteins: Implications for Vaccine Design

Asif M. Khan,
Olivo Miotto,
Eduardo J. M. Nascimento,
K. N. Srinivasan,
A. T. Heiny,
Guang Lan Zhang,
E. T. Marques,
Tin Wee Tan,
Vladimir Brusic,
Jerome Salmon

Published: August 13, 2008
https://doi.org/10.1371/journal.pntd.0000272

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T cells
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Entropy
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Sequence alignment
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Protein sequencing
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