Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

Agnès-Laurence Chenine; Ela Shai-Kobiler; Lisa N. Steele; Helena Ong; Peter Augostini; Ruijiang Song; Sandra J. Lee; Patrick Autissier; Ruth M. Ruprecht; W. Evan Secor

doi:10.1371/journal.pntd.0000265

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Open Access

Peer-reviewed

Research Article

Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

Agnès-Laurence Chenine,

Affiliations Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Ela Shai-Kobiler,

Affiliations Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Lisa N. Steele,

Affiliation Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Helena Ong,

Affiliation Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Peter Augostini,

Affiliation Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Ruijiang Song,

Affiliations Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Sandra J. Lee,

Affiliation Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Patrick Autissier,

Affiliation Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
⨯
Ruth M. Ruprecht ,

* E-mail: ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

Affiliations Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
W. Evan Secor

* E-mail: ruth_ruprecht@dfci.harvard.edu (RMR); was4@cdc.gov (WES)

Affiliation Division of Parasitic Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯

Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

Agnès-Laurence Chenine,
Ela Shai-Kobiler,
Lisa N. Steele,
Helena Ong,
Peter Augostini,
Ruijiang Song,
Sandra J. Lee,
Patrick Autissier,
Ruth M. Ruprecht,
W. Evan Secor

Published: July 23, 2008
https://doi.org/10.1371/journal.pntd.0000265

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This could be due to low DHEA.

Posted by jamesmhoward on 23 Jul 2008 at 20:48 GMT

In 1985 I first suggested that low DHEA may result in HIV infection and that loss of DHEA may actually be the cause of AIDS symptoms. The first reports of low DHEA in AIDS appeared in 1989.

It is known that DHEA protects against schistosomiasis (Clin Infect Dis. 2006 Jun 15;42(12):1692-8). I suggest the findings of Chenine, et al., may represent increased susceptibility to the HIV as a result of already low DHEA.

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Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

Acute Schistosoma mansoni Infection Increases Susceptibility to Systemic SHIV Clade C Infection in Rhesus Macaques after Mucosal Virus Exposure

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This could be due to low DHEA.

Posted by jamesmhoward on 23 Jul 2008 at 20:48 GMT