Schistosomiasis is associated with incident HIV transmission and death in Zambia

Kristin M. Wall; William Kilembe; Bellington Vwalika; Cecile Dinh; Paul Livingston; Yeuk-Mui Lee; Shabir Lakhi; Debi Boeras; Htee Khu Naw; Ilene Brill; Elwyn Chomba; Tyronza Sharkey; Rachel Parker; Erin Shutes; Amanda Tichacek; W. Evan Secor; Susan Allen

doi:10.1371/journal.pntd.0006902

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Open Access

Peer-reviewed

Research Article

Schistosomiasis is associated with incident HIV transmission and death in Zambia

Kristin M. Wall ,

Roles Data curation, Formal analysis, Methodology, Writing – original draft

* E-mail: kmwall@emory.edu

Affiliations Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, Department of Epidemiology, Rollins School of Public Health, Laney Graduate School, Emory University, Atlanta, Georgia, United States of America

http://orcid.org/0000-0001-8547-2004

⨯
William Kilembe,

Roles Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

http://orcid.org/0000-0002-9012-7325

⨯
Bellington Vwalika,

Roles Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliations Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, Department of Gynecology and Obstetrics, School of Medicine, University of Zambia, Lusaka, Zambia
⨯
Cecile Dinh,

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
⨯
Paul Livingston,

Roles Data curation, Formal analysis, Investigation, Project administration, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

http://orcid.org/0000-0002-5096-5148

⨯
Yeuk-Mui Lee †,

† Deceased.

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
Shabir Lakhi,

Roles Conceptualization, Methodology, Project administration, Writing – review & editing

Affiliations Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, Department of Internal Medicine, School of Medicine, University of Zambia, Lusaka, Zambia
⨯
Debi Boeras,

Roles Data curation, Methodology, Project administration, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

http://orcid.org/0000-0002-9850-3479

⨯
Htee Khu Naw,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
⨯
Ilene Brill,

Roles Data curation, Formal analysis, Writing – review & editing

Affiliations Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, Department of Epidemiology, Ryals School of Public Health, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
⨯
Elwyn Chomba,

Roles Conceptualization, Investigation, Methodology, Writing – review & editing

Affiliations Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America, Ministry of Home Affairs, Zambian Ministry of Health, Lusaka, Zambia, School of Medicine, University of Zambia, Lusaka, Zambia
⨯
Tyronza Sharkey,

Roles Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
⨯
Rachel Parker,

Roles Data curation, Supervision, Validation, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
⨯
Erin Shutes,

Roles Conceptualization, Methodology, Resources, Writing – review & editing

Affiliation Malaria Team, Global Health Program, Bill & Melinda Gates Foundation, Seattle, Washington, United States of America
⨯
Amanda Tichacek,

Roles Conceptualization, Investigation, Methodology, Supervision, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America
⨯
W. Evan Secor,

Roles Conceptualization, Investigation, Methodology, Project administration, Resources, Supervision, Writing – review & editing

Affiliation Division of Parasitic Diseases and Malaria, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
⨯
[ ... ],
Susan Allen

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

Affiliation Rwanda Zambia HIV Research Group, Department of Pathology & Laboratory Medicine, School of Medicine and Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America

http://orcid.org/0000-0002-9150-3898

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Schistosomiasis is associated with incident HIV transmission and death in Zambia

Kristin M. Wall,
William Kilembe,
Bellington Vwalika,
Cecile Dinh,
Paul Livingston,
Yeuk-Mui Lee,
Shabir Lakhi,
Debi Boeras,
Htee Khu Naw,
Ilene Brill

Published: December 13, 2018
https://doi.org/10.1371/journal.pntd.0006902

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References to previous work

Posted by ZvBentwich on 20 Feb 2019 at 08:28 GMT

Based on our studies in Ethiopian Immigrants to Israel starting from 1992, we have put forward the hypothesis that helminths' infections (including schistosomiasis) make the host more susceptible to HIV and less able to cope with the infection. These, we argued , are due to the immune activation, the skewed cytokine profile and the increased expression of HIV co receptors-CCR5 and CXCR4. Moreover , we were able to demonstrate that PBMC obtained from these individuals were more susceptible to infection with HIV in vitro. Since these studies and publications preceded all the cited studies in the article, and have likely contributed to the basis for their initiation , I believe they should have been cited in the article.
Bentwich Z, Kalinkovich A & Weisman Z. Immune activation is a dominant factor in the pathogenesis of African AIDS. Immunol Today 1995; 16: 187–191.
Bentwich Z, Kalinkovich A, Weisman Z, Borkow G, Beyers N & Beyers AD. Can eradication of helminthic infections change the face of AIDS and tuberculosis? Immunol Today 1999; 20:485–487.
Kalinkovich A, Borkow G, Weisman Z, Tsimanis A, Stein M& Bentwich Z. Increased CCR5 and CXCR4 expression in Ethiopians living in Israel: environmental and constitutive factors. Clin Immunol 2001; 100: 107–117.
Shapira-Nahor O, Kalinkovich A, Weisman Z et al. Increased susceptibility to HIV-1 infection of peripheral blood mononuclear cells from chronically immune-activated individuals. AIDS 1998; 12: 1731–1733.

No competing interests declared.

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Schistosomiasis is associated with incident HIV transmission and death in Zambia

Schistosomiasis is associated with incident HIV transmission and death in Zambia

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References to previous work

Posted by ZvBentwich on 20 Feb 2019 at 08:28 GMT