Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

Gordana Panic; Mireille Vargas; Ivan Scandale; Jennifer Keiser

doi:10.1371/journal.pntd.0003962

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Open Access

Peer-reviewed

Research Article

Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

Gordana Panic,

Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Mireille Vargas,

Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
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Ivan Scandale,

Affiliation Drugs for Neglected Diseases initiative (DNDi), Geneva, Switzerland
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Jennifer Keiser

* E-mail: jennifer.keiser@unibas.ch

Affiliations Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland
⨯

Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

Gordana Panic,
Mireille Vargas,
Ivan Scandale,
Jennifer Keiser

Published: July 31, 2015
https://doi.org/10.1371/journal.pntd.0003962

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Considering selamectin for Schistosoma mansion treatment?

Posted by santiramongarcia on 24 Aug 2015 at 15:42 GMT

Dear authors,

I have read with attention your work and found that you focused your attention on the avermectin doramectin. Another avermectin, selamectin, was also found on your screen but it was discarded because it was believed to be topically administered. To be noted that selamectin is also orally available.

Coincidentally, we just published in PLOS NTD an analysis of the suitability of the avermectins for Buruli ulcer treatment. See here:

http://journals.plos.org/...

and found that selamectin is the avermectin with the best pharmacokinetic and toxicity profile among all the avermectins. However, it is only used for veterinary medicine.

We are currently exploring its use for Buruli ulcer and for tuberculosis but I believe selamectin is a drug worth exploring for other indications as well.

Best regards,

Santiago Ramon-Garcia

No competing interests declared.

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Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

Activity Profile of an FDA-Approved Compound Library against Schistosoma mansoni

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Considering selamectin for Schistosoma mansion treatment?

Posted by santiramongarcia on 24 Aug 2015 at 15:42 GMT