Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages

Roberto Gimmelli; Giuliana Papoff; Fulvio Saccoccia; Cristiana Lalli; Sandra Gemma; Giuseppe Campiani; Giovina Ruberti

doi:10.1371/journal.pntd.0011992

Loading metrics

Open Access

Peer-reviewed

Research Article

Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages

Roberto Gimmelli,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Roma, Italy
⨯
Giuliana Papoff,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy
⨯
Fulvio Saccoccia,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy
⨯
Cristiana Lalli,

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy
⨯
Sandra Gemma,

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
⨯
Giuseppe Campiani,

Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy
⨯
Giovina Ruberti

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: giovina.ruberti@cnr.it

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy

https://orcid.org/0000-0003-2367-9709

⨯

Effects of structurally distinct human HDAC6 and HDAC6/HDAC8 inhibitors against S. mansoni larval and adult worm stages

Roberto Gimmelli,
Giuliana Papoff,
Fulvio Saccoccia,
Cristiana Lalli,
Sandra Gemma,
Giuseppe Campiani,
Giovina Ruberti

Published: February 28, 2024
https://doi.org/10.1371/journal.pntd.0011992

About the Authors

Roberto Gimmelli

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliations Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy, Dipartimento di Scienze Biochimiche "A. Rossi Fanelli", Sapienza Università di Roma, Roma, Italy

Giuliana Papoff

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy

Fulvio Saccoccia

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy

Cristiana Lalli

Roles Data curation, Formal analysis, Investigation, Methodology

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy

Sandra Gemma

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – review & editing

Affiliation Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy

Giuseppe Campiani

Roles Data curation, Formal analysis, Funding acquisition, Writing – review & editing

Affiliation Department of Biotechnology, Chemistry and Pharmacy, University of Siena, Siena, Italy

Giovina Ruberti

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: giovina.ruberti@cnr.it

Affiliation Institute of Biochemistry and Cell Biology, National Research Council (IBBC-CNR), Adriano Buzzati-Traverso Campus, Monterotondo, Rome, Italy

https://orcid.org/0000-0003-2367-9709

Competing Interests

The authors have declared that no competing interests exist.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Schistosoma mansoni
Is the Subject Area "Schistosoma mansoni" applicable to this article?

Thanks for your feedback.
Eggs
Is the Subject Area "Eggs" applicable to this article?

Thanks for your feedback.
Larvae
Is the Subject Area "Larvae" applicable to this article?

Thanks for your feedback.
Parasitic diseases
Is the Subject Area "Parasitic diseases" applicable to this article?

Thanks for your feedback.
Parasitic life cycles
Is the Subject Area "Parasitic life cycles" applicable to this article?

Thanks for your feedback.
Schistosomiasis
Is the Subject Area "Schistosomiasis" applicable to this article?

Thanks for your feedback.
Tubulins
Is the Subject Area "Tubulins" applicable to this article?

Thanks for your feedback.
Histones
Is the Subject Area "Histones" applicable to this article?

Thanks for your feedback.