Zika virus diversity in mice is maintained during early vertical transmission from placenta to fetus, but reduced in fetal bodies and brains at late stages of infection

Alyssa B. Evans; Clayton W. Winkler; Sarah L. Anzick; Stacy M. Ricklefs; Dan E. Sturdevant; Karin E. Peterson

doi:10.1371/journal.pntd.0011657

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Open Access

Peer-reviewed

Research Article

Zika virus diversity in mice is maintained during early vertical transmission from placenta to fetus, but reduced in fetal bodies and brains at late stages of infection

Alyssa B. Evans ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: alyssa.evans4@montana.edu (ABE); petersonka@niaid.nih.gov (KEP)

Current address: Department of Microbiology and Cell Biology; Montana State University; Bozeman, Montana, United States of America

Affiliation Laboratory of Neurological Infections and Immunity, Neuroimmunology Section; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America
⨯
Clayton W. Winkler,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Laboratory of Neurological Infections and Immunity, Neuroimmunology Section; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America
⨯
Sarah L. Anzick,

Roles Formal analysis, Methodology

Affiliation Genomics Research Section, Research Technologies Branch; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America
⨯
Stacy M. Ricklefs,

Roles Formal analysis, Methodology

Affiliation Genomics Research Section, Research Technologies Branch; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America
⨯
Dan E. Sturdevant,

Roles Formal analysis, Methodology

Affiliation Genomics Research Section, Research Technologies Branch; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America
⨯
Karin E. Peterson

Roles Conceptualization, Writing – review & editing

* E-mail: alyssa.evans4@montana.edu (ABE); petersonka@niaid.nih.gov (KEP)

Affiliation Laboratory of Neurological Infections and Immunity, Neuroimmunology Section; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America

https://orcid.org/0000-0003-4177-7249

⨯

Zika virus diversity in mice is maintained during early vertical transmission from placenta to fetus, but reduced in fetal bodies and brains at late stages of infection

Alyssa B. Evans,
Clayton W. Winkler,
Sarah L. Anzick,
Stacy M. Ricklefs,
Dan E. Sturdevant,
Karin E. Peterson

Published: October 5, 2023
https://doi.org/10.1371/journal.pntd.0011657

About the Authors

Alyssa B. Evans

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

* E-mail: alyssa.evans4@montana.edu (ABE); petersonka@niaid.nih.gov (KEP)

Current address: Department of Microbiology and Cell Biology; Montana State University; Bozeman, Montana, United States of America

Affiliation Laboratory of Neurological Infections and Immunity, Neuroimmunology Section; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America

Clayton W. Winkler

Roles Investigation, Methodology, Writing – review & editing

Sarah L. Anzick

Roles Formal analysis, Methodology

Affiliation Genomics Research Section, Research Technologies Branch; Rocky Mountain Laboratories; National Institute of Allergy and Infectious Diseases (NIAID); National Institutes of Health (NIH); Hamilton, Montana, United States of America

Stacy M. Ricklefs

Roles Formal analysis, Methodology

Dan E. Sturdevant

Roles Formal analysis, Methodology

Karin E. Peterson

Roles Conceptualization, Writing – review & editing

* E-mail: alyssa.evans4@montana.edu (ABE); petersonka@niaid.nih.gov (KEP)

https://orcid.org/0000-0003-4177-7249

Competing Interests

The authors have declared that no competing interests exist.

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Placenta
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Fetuses
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Mouse models
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Zika virus
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RNA sequencing
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Haplotypes
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Genome sequencing
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Nucleotide sequencing
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