Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7

Zhaona Wu; Haris Mirza; Kevin Shyong Wei Tan

doi:10.1371/journal.pntd.0002885

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Open Access

Peer-reviewed

Research Article

Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7

Zhaona Wu ,

Contributed equally to this work with: Zhaona Wu, Haris Mirza

Affiliation Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯
Haris Mirza ,

Contributed equally to this work with: Zhaona Wu, Haris Mirza

Affiliation Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America
⨯
Kevin Shyong Wei Tan

* E-mail: mictank@nus.edu.sg

Affiliation Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
⨯

Intra-Subtype Variation in Enteroadhesion Accounts for Differences in Epithelial Barrier Disruption and Is Associated with Metronidazole Resistance in Blastocystis Subtype-7

Zhaona Wu,
Haris Mirza,
Kevin Shyong Wei Tan

Published: May 22, 2014
https://doi.org/10.1371/journal.pntd.0002885

About the Authors

Zhaona Wu

Contributed equally to this work with: Zhaona Wu, Haris Mirza

Affiliation Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Haris Mirza

Contributed equally to this work with: Zhaona Wu, Haris Mirza

Affiliation Department of Dermatology, Yale School of Medicine, New Haven, Connecticut, United States of America

Kevin Shyong Wei Tan

* E-mail: mictank@nus.edu.sg

Affiliation Laboratory of Molecular and Cellular Parasitology, Department of Microbiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZW HM KSWT. Performed the experiments: ZW. Analyzed the data: ZW HM KSWT. Contributed reagents/materials/analysis tools: KSWT. Wrote the paper: ZW HM KSWT.

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Blastocystis
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Permeability
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Tight junctions
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Parasitic intestinal diseases
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Pathogenesis
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Caco-2 cells
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Gastrointestinal tract
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Intestinal parasites
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