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Zymogens

Mutation in the Pro-Peptide Region of a Cysteine Protease Leads to Altered Activity and Specificity—A Structural and Biochemical Approach

Sruti Dutta, Debi Choudhury, Sumana Roy, Jiban Kanti Dattagupta, Sampa Biswas

published 28 Jun 2016

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Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in Lactation

Chih-Hsin Lai, Ying-Jung J. Lai, Feng-Pai Chou, Hsiang-Hua D. Chang, Chun-Che Tseng, Michael D. Johnson, Jehng-Kang Wang, Chen-Yong Lin

published 04 Apr 2016

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Structural Characterization of the Loop at the Alpha-Subunit C-Terminus of the Mixed Lineage Leukemia Protein Activating Protease Taspase1

Johannes van den Boom, Franziska Trusch, Lukas Hoppstock, Christine Beuck, Peter Bayer

published 14 Mar 2016

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Silencing Mist1 Gene Expression Is Essential for Recovery from Acute Pancreatitis

Anju Karki, Sean E. Humphrey, Rebecca E. Steele, David A. Hess, Elizabeth J. Taparowsky, Stephen F. Konieczny

published 30 Dec 2015

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Enzymatic Characterization of Recombinant Food Vacuole Plasmepsin 4 from the Rodent Malaria Parasite Plasmodium berghei

Peng Liu, Arthur H. Robbins, Melissa R. Marzahn, Scott H. McClung, Charles A. Yowell, Stanley M. Stevens Jr., John B. Dame, Ben M. Dunn

published 28 Oct 2015

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Rab27A Is Present in Mouse Pancreatic Acinar Cells and Is Required for Digestive Enzyme Secretion

Yanan Hou, Stephen A. Ernst, Edward L. Stuenkel, Stephen I. Lentz, John A. Williams

published 07 May 2015

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Protein-Binding RNA Aptamers Affect Molecular Interactions Distantly from Their Binding Sites

Daniel M. Dupont, Cathrine K. Thuesen, Kenneth A. Bøtkjær, Manja A. Behrens, Karen Dam, Hans P. Sørensen, Jan S. Pedersen, Michael Ploug, Jan K. Jensen, Peter A. Andreasen

published 20 Mar 2015

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Differential Subcellular Localization Renders HAI-2 a Matriptase Inhibitor in Breast Cancer Cells but Not in Mammary Epithelial Cells

Hsiang-Hua D. Chang, Yuan Xu, Hongyu Lai, Xiaoyu Yang, Chun-Che Tseng, Ying-Jung J. Lai, Yu Pan, Emily Zhou, Michael D. Johnson, Jehng-Kang Wang, Chen-Yong Lin

published 18 Mar 2015

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Cysteine Protease Profiles of the Medicinal Plant Calotropis procera R. Br. Revealed by De Novo Transcriptome Analysis

Chang Woo Kwon, Kyung-Min Park, Byoung-Cheorl Kang, Dae-Hyuk Kweon, Myoung-Dong Kim, Sang Woon Shin, Yeon Ho Je, Pahn-Shick Chang

published 18 Mar 2015

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Epiplakin Deficiency Aggravates Murine Caerulein-Induced Acute Pancreatitis and Favors the Formation of Acinar Keratin Granules

Karl L. Wögenstein, Sandra Szabo, Mariia Lunova, Gerhard Wiche, Johannes Haybaeck, Pavel Strnad, Peter Boor, Martin Wagner, Peter Fuchs

published 18 Sep 2014

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Matriptase Autoactivation Is Tightly Regulated by the Cellular Chemical Environments

Jehng-Kang Wang, I-Jou Teng, Ting-Jen Lo, Sean Moore, Yee Hui Yeo, Yun-Chung Teng, Malvika Kaul, Chiann-Chyi Chen, Annie Hong Zuo, Fen-Pai Chou, Xiaoyu Yang, I-Chu Tseng, Michael D. Johnson, Chen-Yong Lin

published 04 Apr 2014

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Human Cancer Cells Retain Modest Levels of Enzymatically Active Matriptase Only in Extracellular Milieu following Induction of Zymogen Activation

Li-Ling Chu, Yuan Xu, Jie-Ru Yang, Yi-An Hu, Hsiang-Hua Chang, Hong-Yu Lai, Chun-Che Tseng, Hue-Yu Wang, Michael D. Johnson, Jehng-Kang Wang, Chen-Yong Lin

published 24 Mar 2014

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Disulfide Linkages in Plasmodium falciparum Plasmepsin-I Are Essential Elements for Its Processing Activity and Multi-Milligram Recombinant Production Yield

Sirisak Lolupiman, Pilaiwan Siripurkpong, Jirundon Yuvaniyama

published 20 Feb 2014

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