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Viral replication

A novel oncolytic vaccinia virus with multiple gene modifications involved in viral replication and maturation increases safety for intravenous administration while maintaining proliferative potential in cancer cells

Go Okita, Kiyotaka Suenaga, Masashi Sakaguchi, Toshio Murakami

Zika virus modulates arthropod histone methylation for its survival in mosquito cells

Telvin Harrell, Swarnendu Basak, Hameeda Sultana, Girish Neelakanta

Starve a cold or feed a fever? Identifying cellular metabolic changes following infection and exposure to SARS-CoV-2

Emma K. Loveday, Hope Welhaven, [ ... ], Matthew P. Taylor

Treatment with the CCR5 antagonist OB-002 reduces lung pathology, but does not prevent disease in a Syrian hamster model of SARS-CoV-2 infection

Bryce M. Warner, Robert Vendramelli, [ ... ], Darwyn Kobasa

Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells

Vivian Y. Tat, Aleksandra K. Drelich, [ ... ], George Golovko

The gag-like gene RTL8 antagonizes PEG10-mediated virus like particles

Will Campodonico, Harihar M. Mohan, [ ... ], Alexandra M. Whiteley

Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis

Ali Bigdeli, Mostafa Ghaderi-Zefrehei, [ ... ], S. Shahriar Arab

Eilat virus isolated from Culex univittatus mosquitoes from the Namibian Zambezi Region influences in vitro superinfection with alpha- and flaviviruses in a virus-species-dependent manner

Heiko D. Guggemos, Anne Kopp, [ ... ], Sandra Junglen

Neuron-associated retroelement-derived protein Arc/Arg3.1 assists in the early stages of alphaherpesvirus infection in human neuronal cells

Hiroko Kobayashi, Mitsuki Yasukochi, [ ... ], Satoshi Taharaguchi

Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung

Yoshiro Sugiura, Kenta Shimizu, [ ... ], Wataru Kamitani

Integrated study of Quercetin as a potent SARS-CoV-2 RdRp inhibitor: Binding interactions, MD simulations, and In vitro assays

Ahmed M. Metwaly, Esmail M. El-Fakharany, [ ... ], Ibrahim. H. Eissa

Repurposing of drug candidates against Epstein–Barr virus: Virtual screening, docking computations, molecular dynamics, and quantum mechanical study

Mahmoud A. A. Ibrahim, Alaa M. A. Hassan, [ ... ], Alaa H. M. Abdelrahman

Genetic and pathogenic potential of highly pathogenic avian influenza H5N8 viruses from live bird markets in Egypt in avian and mammalian models

Yassmin Moatasim, Basma Emad Aboulhoda, [ ... ], Rabeh El-Shesheny

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