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Viral replication

Breadth of CD8 T-cell mediated inhibition of replication of diverse HIV-1 transmitted-founder isolates correlates with the breadth of recognition within a comprehensive HIV-1 Gag, Nef, Env and Pol potential T-cell epitope (PTE) peptide set

Peter Hayes, Natalia Fernandez, Christina Ochsenbauer, Jama Dalel, Jonathan Hare, Deborah King, Lucas Black, Claire Streatfield, Vanaja Kakarla, Gladys Macharia, Julia Makinde, Matt Price, Eric Hunter, The IAVI protocol C investigators , Jill Gilmour

published 17 Nov 2021

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Drug repositioning of Clopidogrel or Triamterene to inhibit influenza virus replication in vitro

Nichole Orr-Burks, Jackelyn Murray, Kyle V. Todd, Abhijeet Bakre, Ralph A. Tripp

published 29 Oct 2021

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Leveraging publicly available coronavirus data to identify new therapeutic targets for COVID-19

Stacy L. Sell, Donald S. Prough, Harris A. Weisz, Steve G. Widen, Helen L. Hellmich

published 29 Sep 2021

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Diagnostic accuracy and acceptability of molecular diagnosis of COVID-19 on saliva samples relative to nasopharyngeal swabs in tropical hospital and extra-hospital contexts: The COVISAL study

Mathieu Nacher, Mayka Mergeay-Fabre, Denis Blanchet, Orelie Benois, Tristan Pozl, Pauline Mesphoule, Vincent Sainte-Rose, Véronique Vialette, Bruno Toulet, Aurélie Moua, Mona Saout, Stéphane Simon, Manon Guidarelli, Muriel Galindo, Barbara Biche, William Faurous, Laurie Chaizemartin, Aniza Fahrasmane, Devi Rochemont, Fode Diop, Moussa Niang, Jean Pujo, Nicolas Vignier, Dominique Dotou, Astrid Vabret, Magalie Demar

published 13 Sep 2021

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Direct detection of SARS-CoV-2 antisense and sense genomic RNA in human saliva by semi-autonomous fluorescence in situ hybridization: A proxy for contagiousness?

Gijsbert J. Jansen, Marit Wiersma, Willem J. B. van Wamel, Inge D. Wijnberg

published 17 Aug 2021

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Evaluation of TTV replication as a biomarker of immune checkpoint inhibitors efficacy in melanoma patients

Rémi Pescarmona, William Mouton, Thierry Walzer, Stéphane Dalle, Anaïs Eberhardt, Karen Brengel-Pesce, Marine Villard, Christine Lombard, Sophie Trouillet-Assant, Sébastien Viel

published 09 Aug 2021

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Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies

Claudia Pommerenke, Ulfert Rand, Cord C. Uphoff, Stefan Nagel, Margarete Zaborski, Vivien Hauer, Maren Kaufmann, Corinna Meyer, Sabine A. Denkmann, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Zeljka Macak Safranko, Ivan-Christian Kurolt, Alemka Markotic, Luka Cicin-Sain, Laura Steenpass

published 02 Aug 2021

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Biochemical characterization of protease activity of Nsp3 from SARS-CoV-2 and its inhibition by nanobodies

Lee A. Armstrong, Sven M. Lange, Virginia Dee Cesare, Stephen P. Matthews, Raja Sekhar Nirujogi, Isobel Cole, Anthony Hope, Fraser Cunningham, Rachel Toth, Rukmini Mukherjee, Denisa Bojkova, Franz Gruber, David Gray, Paul G. Wyatt, Jindrich Cinatl, Ivan Dikic, Paul Davies, Yogesh Kulathu

published 16 Jul 2021

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Effects of therapeutic vaccination on the control of SIV in rhesus macaques with variable responsiveness to antiretroviral drugs

Hillary Claire Tunggal, Paul Veness Munson, Megan Ashley O’Connor, Nika Hajari, Sandra Elizabeth Dross, Debra Bratt, James Thomas Fuller, Kenneth Bagley, Deborah Heydenburg Fuller

published 17 Jun 2021

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RNA-guided gene editing of the murine gammaherpesvirus 68 genome reduces infectious virus production

Hui-Chen Chang Foreman, Varvara Kirillov, Gabrielle Paniccia, Demetra Catalano, Trevor Andrunik, Swati Gupta, Laurie T. Krug, Yue Zhang

published 04 Jun 2021

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Avian antibodies (IgY) targeting spike glycoprotein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit receptor binding and viral replication

Chad Artman, Kyle D. Brumfield, Sahil Khanna, Julius Goepp

published 28 May 2021

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SARS-CoV-2: Possible recombination and emergence of potentially more virulent strains

Dania Haddad, Sumi Elsa John, Anwar Mohammad, Maha M. Hammad, Prashantha Hebbar, Arshad Channanath, Rasheeba Nizam, Sarah Al-Qabandi, Ashraf Al Madhoun, Abdullah Alshukry, Hamad Ali, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

published 25 May 2021

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The combination of the NS5A and cyclophilin inhibitors results in an additive anti-HCV inhibition in humanized mice without development of resistance

Michael Bobardt, Christina M. Ramirez, Marc M. Baum, Daren Ure, Robert Foster, Philippe A. Gallay

published 20 May 2021

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