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Toxicity

TunR2, a novel mode-of-action tunicamycin-type antibiotic: Pharmacokinetics in C57BL/6 mouse and Holstein cattle

Maria A. Colombatti Olivieri, Eric D. Cassmann, Michael A. Jackson, Neil P. J. Price, John P. Bannantine

published 23 Jul 2025

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Assessment of tannery effluents quality treated by electrocoagulation and ozonation: Physicochemical and ecotoxicological characterization

Edwar Aguilar-Ascón, Liliana Marrufo-Saldaña, Julio Barra-Hinojosa, Robert Buleje-del-Carpio

published 22 Jul 2025

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Targeted modulation of MMP9 and GRP78 via molecular interaction and in silico profiling of Curcuma caesia rhizome metabolites: A computational drug discovery approach for cancer therapy

Mahek Desai, Soham Bhattacharya, Saurabhkumar Mehta, Kaushiki Joshi, Mitesh B. Solanki, Trilok Akhani, Iva Viehmannová, Eloy Fernández Cusimamani

published 18 Jul 2025

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Evaluation of Sub-acute toxicity and safety profile of Charmagaz seed oil in rats

Anum Adil, Saira Saeed Khan, Sadaf Naeem, Ali Alqahtani, Taha Alqahtani, Ali Asgher Shuja, Anosh Tahir

published 11 Jul 2025

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Biweekly CAPOX versus triweekly CAPOX in the adjuvant therapy of post-surgery CRC: A randomized controlled trial

Hangyu Zhang, Danyang Wang, Zhou Tong, Tao Xiang, Xudong Zhu, Lulu Liu, Yi Zheng, Peng Zhao, Weijia Fang, Wenbin Chen

published 11 Jul 2025

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Exploration of effective pharmacological inhibitors for NS5 protein through computational approach: A strategy to combat the neglected Kyasanur forest disease virus

Sharanappa Achappa, Nayef Abdulaziz Aldabaan, Mohammed Alasmary, Ibrahim Ahmed Shaikh, Mater H. Mahnashi, Shivalingsarj V. Desai, Uday M. Muddapur, Aejaz Abdullatif Khan, Basheerahmed Abdulaziz Mannasaheb

published 10 Jul 2025

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Diversity of Aβ aggregates produced in a gut-based Drosophila model of Alzheimer’s disease

Greta Elovsson, Therése Klingstedt, K. Peter R. Nilsson, Ann-Christin Brorsson

published 08 Jul 2025

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Therapeutic patterns and outcomes in older patients (aged ≥ 65 years) with stage III inoperable non-small cell lung cancer (NSCLC): An investigational study from the SEER database

Wangyan Zhong, Hang Yuan, Ting Li, Xueying Jin

published 03 Jul 2025

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Copper supplementation enhances pigmentation and induces dopamine production in ARPE19

Hironori Uehara, Baila Shakaib, Sangeetha Ravi Kumar, Bonnie Archer, Balamurali Ambati

published 01 Jul 2025

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Helpful assistant or fruitful facilitator? Investigating how personas affect language model behavior

Pedro Henrique Luz de Araujo, Benjamin Roth

published 30 Jun 2025

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Influence of capping agents on physicochemical properties and leukemic cytotoxicity of copper oxide nanoparticles biosynthesized using Caesalpinia sappan extract

Mathurada Sasarom, Songyot Anuchapreeda, Wim E. Hennink, Siriporn Okonogi

published 26 Jun 2025

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SHR-A1811, a novel anti-HER2 antibody–drug conjugate with optimal drug-to-antibody ratio, efficient tumor killing potency, and favorable safety profiles

Ting Zhang, Jianyan Xu, Junzhao Yin, Yun Gao, Hanwen Zheng, Beibei Fu, Jiakang Sun, Zhibin Xu, Shiwei Tu, Yuchang Mao, Weiyun Wen, Bolei Qu, Lingfeng You, Zhendong Xue, Xing Sun, Dan Cao, Jun Feng, Min Hu, Feng He

published 26 Jun 2025

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Efficacy and safety of cisplatin + docetaxel + 5-FU + leucovorin + methotrexate and epirubicin combination chemotherapy for advanced esophageal cancer

Sung-Chi Yu, Shao-Syuan Tong, Yi-Ling Chen, Ya-Fu Cheng, Jin-Ching Lin, Ching-Yuan Cheng, Chang-Lun Huang, Wei-Heng Hu, Bing-Yen Wang

published 26 Jun 2025

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