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Toxicity

Computational screening of natural inhibitors against Plasmodium falciparum kinases: Toward novel antimalarial therapies

Muharib Alruwaili, Sonia Younas, Abozer Y. Elderdery, Intisar Alruwaili, Jeremy Millis, Muhammad Umer Khan, Hasan Ejaz

published 13 Jan 2026

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Vinyl chloride oligomers: On the road to understand the potential toxicity of PVC nanoplastics

Esperanza Quevedo, Emiliano Perez-Sanchez, Alexis Caballero, Ana Martínez

published 12 Jan 2026

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Opioid dispensing prior to opioid toxicity hospitalizations and emergency department visits in Canada, 2018–2022

Bisola Hamzat, Grace Cheung, Dean T. Eurich, Jean-Luc Kaboré, Louis de Léséleuc, Zhaoyu Liu, Daniel McCormack, Houssem Missaoui, Jason R. Randall, Dana Shearer, David Stock, Tara Gomes

published 12 Jan 2026

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Safety and therapeutic potential evaluation of Cefotaxime plus Polymyxin B against polymyxin-carbapenem resistant Klebsiella pneumoniae in a murine model

Mariana Carvalho Sturaro, Nathalia da Silva Damaceno, Gleyce Hellen de Almeida de Souza, José Eduardo Souza Echeverria, Ediane Bortolotte Cornelius, Luccas Pereira Pires, Pedro Vinícius Dias Bassetto Silva, Bárbara Maria Cristaldo Gomes, Thiago Leite Fraga, Osmar Nascimento Silva, Luana Rossato, Simone Simionatto

published 05 Jan 2026

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Screening anticancer activity by Brine shrimp lethality test of extracts of Annona stenophylla (Engl. & Diels), Strophanthus petersianus (Klotzsch) and Synadenium glaucescens (Pax)

Roberto Luis Nhamussua, Faith Philemone Mabiki, Alinanuswe Joel Mwakalesi, Lyndy Joy McGaw

published 02 Jan 2026

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Integrating bioactivity and molecular simulations to explore the pharmacological landscape of Lagerstroemia speciosa leaf extract

Md Shajedul Haque, Rubel Ahmad, Bidhan Chandra Sarkar, Manoshi Sana, Hasi Rani Saha, Niranjan Kumar Sana

published 29 Dec 2025

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Development of a CYP2D6-enhanced HepaRG cell model with improved CYP2D6 metabolic capacity

Chizuka Obara, Yohei Iizaka, Akari Mine, Yojiro Anzai, Masako Tada, Shinpei Yamaguchi

published 29 Dec 2025

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Functional beverage development from traditional Thai polyherbal tonic: Antioxidant-rich microcapsules and comprehensive sub-chronic toxicity assessment

Thammarat Kaewmanee, Acharaporn Issuriya, Piyapong Choochana, Pinanong Na-Phatthalung, Surasak Limsuwan, Sasitorn Chusri

published 23 Dec 2025

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Preclinical safety and burn wound healing activity of “Novostron”, a novel topical iodine-based therapeutic

Nailya Ibragimova, Arailym Aitynova, Seitzhan Turganbay, Marina Lyu, Alexandr Ilin, Tamari Gapurkhaeva, Galina Ponomareva, Karina Vassilyeva, Diana Issayeva, Amirkan Azembayev, Serzhan Mombekov, Aralbek Rsaliyev, Nurgul Sikhayeva, Yergali Abduraimov, Saki Raheem

published 12 Dec 2025

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Machine learning-guided identification and simulation-based validation of potent JAK3 inhibitors for cancer therapy

Hailang Wei, Qingyun Wang

published 12 Dec 2025

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Impacts of polymorphisms in drug-metabolizing enzyme and transporter genes on irinotecan toxicity and efficacy in Thai colorectal cancer patients

Natthakul Akarapredee, Chalirmporn Atasilp, Chonlaphat Sukasem, Pimonpan Jinda, Rattanaporn Sukprasong, Jiraporn Jensuriyarkun, Soravit Wongjitjanyong, Patompong Satapornpong, Natchaya Vanwong

published 12 Dec 2025

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In silico investigation of novel Plasmodium Falciparum glycogen synthase kinase (pfGSk3β) inhibitors for the treatment of malaria infection

Kassim Folorunsho Adebambo, Sara Otify

published 08 Dec 2025

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Lactate-to-albumin ratio and albumin-corrected anion gap as predictors of outcome in methanol poisoning: A retrospective observational study

İlter Ağaçkıran, Merve Ağaçkıran

published 04 Dec 2025

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