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T cells

Anti-CTLA-4 treatment suppresses hepatocellular carcinoma growth through Th1-mediated cell cycle arrest and apoptosis

Hitomi Morihara, Tomomi Yamada, Yumi Tona, Marina Akasaka, Hirohisa Okuyama, Natsumi Chatani, Satomi Shinonome, Azumi Ueyama, Kenji Kuwabara, Yasushi Fujio

published 06 Aug 2024

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Head-to-head comparison of composite and individual biomarkers to predict clinical benefit to PD-1 blockade in non-small cell lung cancer

Karlijn Hummelink, Vincent van der Noort, Mirte Muller, Robert D. Schouten, Michel M. van den Heuvel, Daniela S. Thommen, Egbert F. Smit, Gerrit A. Meijer, Kim Monkhorst

published 31 Jul 2024

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Comprehensive integrated single-cell RNA sequencing analysis of brain metastasis and glioma microenvironment: Contrasting heterogeneity landscapes

Seyedeh Fatemeh Sajjadi, Najmeh Salehi, Mehdi Sadeghi

published 26 Jul 2024

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Tumor immune microenvironment permissive to metastatic progression of ING4-deficient breast cancer

Emily Tsutsumi, Anne M. Macy, Janine LoBello, Karen T. Hastings, Suwon Kim

published 05 Jul 2024

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Immune cells and checkpoints in pancreatic adenocarcinoma: Association with clinical and pathological characteristics

Maria Auxiliadora de Paula Carneiro Cysneiros, Magno Belém Cirqueira, Lucas de Figueiredo Barbosa, Ênio Chaves de Oliveira, Lucio Kenny Morais, Isabela Jubé Wastowski, Vitor Gonçalves Floriano

published 02 Jul 2024

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Heligmosomoides bakeri and Toxoplasma gondii co-infection leads to increased mortality associated with changes in immune resistance in the lymphoid compartment and disease pathology

Edina K. Szabo, Christina Bowhay, Emma Forrester, Holly Liu, Beverly Dong, Aralia Leon Coria, Shashini Perera, Beatrice Fung, Namratha Badawadagi, Camila Gaio, Kayla Bailey, Manfred Ritz, Joel Bowron, Anupama Ariyaratne, Constance A. M. Finney

published 01 Jul 2024

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Novel hematopoietic progenitor kinase 1 inhibitor KHK-6 enhances T-cell activation

Min Jeong Ahn, Eun Hye Kim, Yunha Choi, Chong Hak Chae, Pilho Kim, Seong Hwan Kim

published 26 Jun 2024

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Intermittent hypoxia induces Th17/Treg imbalance in a murine model of obstructive sleep apnea

Do-Yang Park, Chang-Hoon Kim, Da-Young Park, Hyun Jun Kim, Hyung-Ju Cho

published 24 Jun 2024

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Pathway analysis of peripheral blood CD8+ T cell transcriptome shows differential regulation of sphingolipid signaling in multiple sclerosis and glioblastoma

Milan Stefanović, Ivan Jovanović, Maja Živković, Aleksandra Stanković

published 11 Jun 2024

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Sequence, structure prediction, and epitope analysis of the polymorphic membrane protein family in Chlamydia trachomatis

Patrick W. Cervantes, Brent W. Segelke, Edmond Y. Lau, Beverly V. Robinson, Abisola Abisoye-Ogunniyan, Sukumar Pal, Luis M. de la Maza, Matthew A. Coleman, Patrik D’haeseleer

published 11 Jun 2024

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Proinsulin degradation and presentation of a proinsulin B-chain autoantigen involves ER-associated protein degradation (ERAD)-enzyme UBE2G2

Tom Cremer, Hanneke Hoelen, Michael L. van de Weijer, George M. Janssen, Ana I. Costa, Peter A. van Veelen, Robert Jan Lebbink, Emmanuel J. H. J. Wiertz

published 24 May 2024

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Programmed cell death-1 is involved with peripheral blood immune cell profiles in patients with hepatitis C virus antiviral therapy

Miyabi Miura, Michiko Nishino, Kazunori Kawaguchi, Shihui Li, Tetsuro Shimakami, Toshikatsu Tamai, Hidetoshi Nakagawa, Takeshi Terashima, Noriho Iida, Hajime Takatori, Kuniaki Arai, Yoshio Sakai, Tatsuya Yamashita, Masao Honda, Shuichi Kaneko, Eishiro Mizukoshi, Taro Yamashita

published 23 May 2024

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KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B

Li Wang, Fangli Liao, Liping Yang, Linshan Jiang, Liang Duan, Bo Wang, Di Mu, Juan Chen, Ying Huang, Qin Hu, Weixian Chen

published 22 May 2024

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