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Substitution mutation

fosA3 overexpression with transporter mutations mediates high-level of fosfomycin resistance and silence of fosA3 in fosfomycin-susceptible Klebsiella pneumoniae producing carbapenemase clinical isolates

Uthaibhorn Singkham-in, Netchanok Muhummudaree, Tanittha Chatsuwan

published 28 Aug 2020

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The lack of K13-propeller mutations associated with artemisinin resistance in Plasmodium falciparum in Democratic Republic of Congo (DRC)

Doudou Malekita Yobi, Nadine Kalenda Kayiba, Dieudonné Makaba Mvumbi, Raphael Boreux, Sebastien Bontems, Pius Zakayi Kabututu, Patrick De Mol, Niko Speybroeck, Georges Lelo Mvumbi, Marie-Pierre Hayette

published 21 Aug 2020

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Molecular detection of multidrug resistance pattern and associated gene mutations in M. tuberculosis isolates from newly diagnosed pulmonary tuberculosis patients in Addis Ababa, Ethiopia

Melaku Tilahun, Ezra Shimelis, Teklu Wogayehu, Gebeyehu Assefa, Getachew Wondimagegn, Alemayehu Mekonnen, Tsegaye Hailu, Kidist Bobosha, Abraham Aseffa

published 04 Aug 2020

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An Angelman syndrome substitution in the HECT E3 ubiquitin ligase C-terminal Lobe of E6AP affects protein stability and activity

Steven A. Beasley, Chloe E. Kellum, Rachel J. Orlomoski, Feston Idrizi, Donald E. Spratt

published 08 Jul 2020

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Whole-genome sequencing reveals origin and evolution of influenza A(H1N1)pdm09 viruses in Lincang, China, from 2014 to 2018

Xiao-Nan Zhao, Han-Ju Zhang, Duo Li, Jie-Nan Zhou, Yao-Yao Chen, Yan-Hong Sun, Adeniyi C. Adeola, Xiao-Qing Fu, Yong Shao, Mei-Ling Zhang

published 24 Jun 2020

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Pre-existing minor variants with NS5A L31M/V-Y93H double substitution are closely linked to virologic failure with asunaprevir plus daclatasvir treatment for genotype 1b hepatitis C virus infection

Naoki Morishita, Ryotaro Sakamori, Tomomi Yamada, Yugo Kai, Yuki Tahata, Ayako Urabe, Ryoko Yamada, Takahiro Kodama, Hayato Hikita, Yoshinori Doi, Shinji Tamura, Hideki Hagiwara, Yasuharu Imai, Sadaharu Iio, Tomohide Tatsumi, Tetsuo Takehara

published 16 Jun 2020

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Adapting Biased Gene Conversion theory to account for intensive GC-content deterioration in the human genome by novel mutations

Rajan Paudel, Larisa Fedorova, Alexei Fedorov

published 30 Apr 2020

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Pre-existing resistance associated polymorphisms to NS3 protease inhibitors in treatment naïve HCV positive Pakistani patients

Hafeez Ullah Khan, Sanaullah Khan, Muhammad Akbar Shah, Sobia Attaullah, Muhammad Arshad Malik

published 10 Apr 2020

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Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

published 09 Apr 2020

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Polymorphisms and drug resistance analysis of HIV-1 isolates from patients on first line antiretroviral therapy (ART) in South-eastern Nigeria

Augustine O. Udeze, David O. Olaleye, Georgina N. Odaibo

published 08 Apr 2020

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R409K mutation prevents acid-induced aggregation of human IgG4

Hiroshi Namisaki, Seiji Saito, Keiko Hiraishi, Tomoko Haba, Yoshitaka Tanaka, Hideaki Yoshida, Shigeru Iida, Nobuaki Takahashi

published 17 Mar 2020

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Epidemic of influenza A(H1N1)pdm09 analyzed by full genome sequences and the first case of oseltamivir-resistant strain in Myanmar 2017

Su Mon Kyaw Win, Reiko Saito, Nay Chi Win, Di Ja Lasham, Yadanar Kyaw, Nay Lin, Khin Nyo Thein, Irina Chon, Takashi Odagiri, Win Thein, Latt Latt Kyaw, Ommar Swe Tin, Akihiko Saitoh, Tsutomu Tamura, Chika Hirokawa, Yuko Uchida, Takehiko Saito, Shinji Watanabe, Takato Odagiri, Kazuhiro Kamata, Hidekazu Osada, Clyde Dapat, Hisami Watanabe, Htay Htay Tin

published 04 Mar 2020

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Tryptophan residue 32 in human Cu-Zn superoxide dismutase modulates prion-like propagation and strain selection

Anthony Crown, Luke McAlary, Eric Fagerli, Hilda Brown, Justin J. Yerbury, Ahmad Galaleldeen, Neil R. Cashman, David R. Borchelt, Jacob I. Ayers

published 30 Jan 2020

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