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Solubility

Modifications in the piperazine ring of nucleozin affect anti-influenza activity

Erick Correa-Padilla, Alejandro Hernández-Cano, Gabriel Cuevas, Yunuen Acevedo-Betancur, Fernando Esquivel-Guadarrama, Karina Martinez-Mayorga

published 10 Feb 2023

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Structure-function relationships of cholesterol mobilization from the endo-lysosome compartment of NPC1-deficient human cells by β-CD polyrotaxanes

Shayak Samaddar, Debosreeta Bose, Bradley P. Loren, Joseph L. Skulsky, Olga Ilnytska, Zachary J. Struzik, Judith Storch, David H. Thompson

published 30 Dec 2022

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Phenotypic screening of 1,953 FDA-approved drugs reveals 26 hits with potential for repurposing for Peyronie’s disease

Marcus M. Ilg, Alice R. Lapthorn, David J. Ralph, Selim Cellek

published 12 Dec 2022

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Synthesis, characterization, and in vivo safety evaluation of propylated Dioscorea abyssinica starch

Yonas Brhane, Tsige Gebre-Mariam, Anteneh Belete

published 28 Nov 2022

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Preparation, characterization, and evaluation (in-vitro, ex-vivo, and in-vivo) of naturosomal nanocarriers for enhanced delivery and therapeutic efficacy of hesperetin

Shailendra Gurav, Poonam Usapkar, Nilambari Gurav, Sameer Nadaf, Muniappan Ayyanar, Rucheera Verekar, Ritesh Bhole, Chintha Venkataramaiah, Goutam Jena, Rupesh Chikhale

published 03 Nov 2022

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Development and in vitro characterization of a humanized scFv against fungal infections

Tomas Di Mambro, Tania Vanzolini, Marzia Bianchi, Rita Crinelli, Barbara Canonico, Filippo Tasini, Michele Menotta, Mauro Magnani

published 31 Oct 2022

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Identification of natural cytochalasins as leads for neglected tropical diseases drug discovery

Marilia Valli, Julia Medeiros Souza, Rafael Consolin Chelucci, Carolina Rabal Biasetto, Angela Regina Araujo, Vanderlan da Silva Bolzani, Adriano Defini Andricopulo

published 03 Oct 2022

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Solubility affects IL-1β-producing activity of the synthetic candidalysin peptide

Taiki Mori, Hideo Kataoka, Gen Tanabe, Takeshi Into

published 30 Aug 2022

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Fe³⁺ opposes the 1,25(OH)₂D₃-induced calcium transport across intestinal epithelium-like Caco-2 monolayer in the presence or absence of ascorbic acid

Sukpapohn Phummisutthigoon, Kornkamon Lertsuwan, Nattapon Panupinthu, Ratchaneevan Aeimlapa, Jarinthorn Teerapornpuntakit, Wasutorn Chankamngoen, Jirawan Thongbunchoo, Narattaphol Charoenphandhu, Kannikar Wongdee

published 30 Aug 2022

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13-amino derivatives of dehydrocostus lactone display greatly enhanced selective toxicity against breast cancer cells and improved binding energies to protein kinases in silico

Douglas Kemboi, Moses K. Langat, Xavier Siwe-Noundou, Tendamudzimu Tshiwawa, Rui W. M. Krause, Candace Davison, Christie Jane Smit, Jo-Anne de la Mare, Vuyelwa Jacqueline Tembu

published 23 Aug 2022

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Fusion with heat-resistant obscure (Hero) proteins have the potential to improve the molecular property of recombinant proteins

Eri Morimoto, Kotaro Tsuboyama, Yukihide Tomari

published 17 Jun 2022

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Pre-clinical evaluation of LASSBio-1491: From in vitro pharmacokinetic study to in vivo leishmanicidal activity

Aline Cavalcanti de Queiroz, Gisele Barbosa, Victória Regina Thomaz de Oliveira, Hélio de Mattos Alves, Marina Amaral Alves, Vanessa Carregaro, João Santana da Silva, Eliezer Jesus Barreiro, Magna Suzana Alexandre-Moreira, Lidia Moreira Lima

published 06 Jun 2022

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Potential of antiviral peptide-based SARS-CoV-2 inactivators to combat COVID-19

Arun Bahadur Gurung, Mohammad Ajmal Ali, Joongku Lee, Mohamed El-Zaidy, Reem M. Aljowaie, Saeedah M. Almutairi

published 03 Jun 2022

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