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Solubility

New polymorph of tofacitinib citrate and in vitro equivalence study of its sustained-release tablets

Yan Wang, Shuai Wen, Yao Zhao, Lijuan Gui, Yi Mou, Dongkai Wang

published 14 Oct 2025

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A water solubility prediction algorithm based on the StackBoost model

Bin Pan, Xiaoyu Hou, Mingxin Zhang, Jingxian Yu, Conghui Zhang, Yunhui Zhang, Xiaolong Su, Shuangcai Li

published 29 Aug 2025

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Water-soluble vidarabine derivatives alleviate catecholamine-induced heart failure and arrhythmia without impairing cardiac function in mice

Kenji Suita, Yoshio Hayakawa, Yujiro Hoshino, Wenqian Cai, Reiko Kurotani, Yoshiki Ohnuki, Yasumasa Mototani, Yoshihiro Ishikawa, Satoshi Okumura

published 20 Aug 2025

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Cloning and enhancing lumbrokinase production from local Eisenia fetida by signal peptide engineering for effective thrombosis treatment

Adeeba Tabassum, Nadia Zeeshan, Amber Afroz

published 24 Jul 2025

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G91-deletion in βA3/A1-crystallin induces cellular and molecular changes in mouse lenses leading to congenital cataract development

Akosua K. Boateng, Roy Joseph, Om P. Srivastava

published 07 Jul 2025

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Exploring varicella zoster virus proteome for construction and validation of a multi-epitope based subunit vaccine using multifaceted immunoinformatics approaches

Yassir A. Almofti, Amna A. Ibrahim, Nuha A. Mahmoud, Abdelmajeed M. Elshafei, Nosiba Ibrahim, Ibrahim Albokhadaim, Saad Shousha, Ahmed O. Alameen, Nawal Elkhair, Mahmoud G. El Sebaei, Mahmoud Kandeel, Samir Alhojaily, Sheryar Afzal, Mohammed Ali Al-Hammadi, Ghada M, Ali Attiq, Yuan-Seng Wu

published 24 Jun 2025

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Dermal formulation based on carbopol and Gum Arabic improves skin retention of indomethacin

Hiroko Otake, Ogata Fumihiko, Yosuke Nakazawa, Manju Misra, Masanobu Tsubaki, Naohito Kawasaki, Noriaki Nagai

published 10 Jun 2025

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Overestimated cytotoxicity and underestimated whitening efficacy of glabridin: A result of its poor solubility in DMSO

Haiyan Liu, Anning Wang, Xiaoyi Chen, Sen Hou, Anzhang Li

published 06 Jun 2025

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Investigation of hydrolysis of olmesartan medoxomil in different pH buffers by simultaneously measuring olmesartan medoxomil and olmesartan

Lauren Landry, Xiaowei Dong

published 02 May 2025

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A minimal biophysical model for the temperature dependence of CO₂ fixation rates based on macromolecular rate theory

Erica J. Prentice, Margaret M. Barbour, Vickery L. Arcus

published 17 Apr 2025

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Preparation of a solid dispersion of Euptox A and evaluation of its biological activity and safety

Haojun Li, Runa Zhao, Wei Zhou, Zhili Li, Wenlong Chen

published 27 Mar 2025

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Challenges and strategies in the soluble expression of CTA1-(S14P5)4-DD and CTA1-(S21P2)4-DD fusion proteins as candidates for COVID-19 intranasal vaccines

Simson Tarigan, Gita Sekarmila, Apas, Sumarningsih, Ronald Tarigan, Riyandini Putri, Damai Ria Setyawati

published 26 Dec 2024

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Preparation and cell imaging of a nido-carborane fluorescent complex based on multi-component polymerization

Hezhong Ouyang, Zhou Wang, Min Liu

published 12 Dec 2024

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