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Solid state physics

New Insight into the Transcarbamylase Family: The Structure of Putrescine Transcarbamylase, a Key Catalyst for Fermentative Utilization of Agmatine

Luis Mariano Polo, Fernando Gil-Ortiz, Angel Cantín, Vicente Rubio

published 20 Feb 2012

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Structure-Based Rational Design of a Toll-like Receptor 4 (TLR4) Decoy Receptor with High Binding Affinity for a Target Protein

Jieun Han, Hyun Jung Kim, Sang-Chul Lee, Seungpyo Hong, Keunwan Park, Young Ho Jeon, Dongsup Kim, Hae-Kap Cheong, Hak-Sung Kim

published 17 Feb 2012

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Novel Covalently Linked Insulin Dimer Engineered to Investigate the Function of Insulin Dimerization

Tine N. Vinther, Mathias Norrman, Holger M. Strauss, Kasper Huus, Morten Schlein, Thomas Å. Pedersen, Thomas Kjeldsen, Knud J. Jensen, František Hubálek

published 17 Feb 2012

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Crystal Structure of TDRD3 and Methyl-Arginine Binding Characterization of TDRD3, SMN and SPF30

Ke Liu, Yahong Guo, Haiping Liu, Chuanbing Bian, Robert Lam, Yongsong Liu, Farrell Mackenzie, Luis Alejandro Rojas, Danny Reinberg, Mark T. Bedford, Rui-Ming Xu, Jinrong Min

published 17 Feb 2012

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Recognition of Anesthetic Barbiturates by a Protein Binding Site: A High Resolution Structural Analysis

Simon Oakley, L. Sangeetha Vedula, Weiming Bu, Qing Cheng Meng, Jin Xi, Renyu Liu, Roderic G. Eckenhoff, Patrick J. Loll

published 16 Feb 2012

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Novel Information on the Epitope of an Inverse Agonist Monoclonal Antibody Provides Insight into the Structure of the TSH Receptor

Chun-Rong Chen, Larry M. Salazar, Sandra M. McLachlan, Basil Rapoport

published 16 Feb 2012

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The S4–S5 Linker Acts as a Signal Integrator for hERG K⁺ Channel Activation and Deactivation Gating

Chai Ann Ng, Matthew D. Perry, Peter S. Tan, Adam P. Hill, Philip W. Kuchel, Jamie I. Vandenberg

published 16 Feb 2012

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Tetrahydrodipicolinate N-Succinyltransferase and Dihydrodipicolinate Synthase from Pseudomonas aeruginosa: Structure Analysis and Gene Deletion

Robert Schnell, Wulf Oehlmann, Tatyana Sandalova, Yvonne Braun, Carmen Huck, Marko Maringer, Mahavir Singh, Gunter Schneider

published 16 Feb 2012

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Evolution of Resistance to Aurora Kinase B Inhibitors in Leukaemia Cells

Timothy W. Failes, Gorjana Mitic, Heba Abdel-Halim, Sela T. Po'uha, Marjorie Liu, David E. Hibbs, Maria Kavallaris

published 16 Feb 2012

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Structure Based Discovery of Small Molecules to Regulate the Activity of Human Insulin Degrading Enzyme

Bilal Çakir, Onur Dağliyan, Ezgi Dağyildiz, İbrahim Bariş, Ibrahim Halil Kavakli, Seda Kizilel, Metin Türkay

published 15 Feb 2012

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Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

Kishore Viswanathan, Kathleen M. Frey, Eric W. Scocchera, Brooke D. Martin, P. Whitney Swain III, Jeremy B. Alverson, Nigel D. Priestley, Amy C. Anderson, Dennis L. Wright

published 07 Feb 2012

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Identification of Anti-Malarial Compounds as Novel Antagonists to Chemokine Receptor CXCR4 in Pancreatic Cancer Cells

Joseph Kim, M. L. Richard Yip, Xiaoming Shen, Hubert Li, Li-Yu Charlie Hsin, Samuel Labarge, Eileen L. Heinrich, Wendy Lee, Jianming Lu, Nagarajan Vaidehi

published 03 Feb 2012

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Homology Inference of Protein-Protein Interactions via Conserved Binding Sites

Manoj Tyagi, Ratna R. Thangudu, Dachuan Zhang, Stephen H. Bryant, Thomas Madej, Anna R. Panchenko

published 31 Jan 2012

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