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Solid state physics

Substantial Conformational Change Mediated by Charge-Triad Residues of the Death Effector Domain in Protein-Protein Interactions

Edward C. Twomey, Dana F. Cordasco, Stephen D. Kozuch, Yufeng Wei

published 31 Dec 2013

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Kinetic and Structural Studies of Aldehyde Oxidoreductase from Desulfovibrio gigas Reveal a Dithiolene-Based Chemistry for Enzyme Activation and Inhibition by H₂O₂

Jacopo Marangon, Hugo D. Correia, Carlos D. Brondino, José J. G. Moura, Maria J. Romão, Pablo J. González, Teresa Santos-Silva

published 31 Dec 2013

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Unfolding Simulations of Holomyoglobin from Four Mammals: Identification of Intermediates and β-Sheet Formation from Partially Unfolded States

Pouria Dasmeh, Kasper P. Kepp

published 27 Dec 2013

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Tricyclic GyrB/ParE (TriBE) Inhibitors: A New Class of Broad-Spectrum Dual-Targeting Antibacterial Agents

Leslie W. Tari, Xiaoming Li, Michael Trzoss, Daniel C. Bensen, Zhiyong Chen, Thanh Lam, Junhu Zhang, Suk Joong Lee, Grayson Hough, Doug Phillipson, Suzanne Akers-Rodriguez, Mark L. Cunningham, Bryan P. Kwan, Kirk J. Nelson, Amanda Castellano, Jeff B. Locke, Vickie Brown-Driver, Timothy M. Murphy, Voon S. Ong, Chris M. Pillar, Dean L. Shinabarger, Jay Nix, Felice C. Lightstone, Sergio E. Wong, Toan B. Nguyen, Karen J. Shaw, John Finn

published 26 Dec 2013

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Crystal Structures and Molecular Dynamics Simulations of Thermophilic Malate Dehydrogenase Reveal Critical Loop Motion for Co-Substrate Binding

Chih-Hung Hung, Tzann-Shun Hwang, Yu-Yung Chang, Huei-Ru Luo, Szu-Pei Wu, Chun-Hua Hsu

published 26 Dec 2013

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Chemical Synthesis and Biological Activities of Novel Pleuromutilin Derivatives with Substituted Amino Moiety

Ruofeng Shang, Shengyu Wang, Ximing Xu, Yunpeng Yi, Wenzhu Guo, YuLiu, Jianping Liang

published 23 Dec 2013

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Inhibition of Human Neutrophil Elastase by Pentacyclic Triterpenes

Li Feng, Xiaoyu Liu, Weiliang Zhu, Fujiang Guo, YingchunWu, Rui Wang, Kaixian Chen, Cheng Huang, Yiming Li

published 20 Dec 2013

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APOBEC3G Oligomerization Is Associated with the Inhibition of Both Alu and LINE-1 Retrotransposition

Takayoshi Koyama, Juan Fernando Arias, Yukie Iwabu, Masaru Yokoyama, Hideaki Fujita, Hironori Sato, Kenzo Tokunaga

published 19 Dec 2013

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Structural Context of Disease-Associated Mutations and Putative Mechanism of Autoinhibition Revealed by X-Ray Crystallographic Analysis of the EZH2-SET Domain

Stephen Antonysamy, Bradley Condon, Zhanna Druzina, Jeffrey B. Bonanno, Tarun Gheyi, Feiyu Zhang, Iain MacEwan, Aiping Zhang, Sheela Ashok, Logan Rodgers, Marijane Russell, John Gately Luz

published 19 Dec 2013

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Structure of the Catalytic Domain of EZH2 Reveals Conformational Plasticity in Cofactor and Substrate Binding Sites and Explains Oncogenic Mutations

Hong Wu, Hong Zeng, Aiping Dong, Fengling Li, Hao He, Guillermo Senisterra, Alma Seitova, Shili Duan, Peter J. Brown, Masoud Vedadi, Cheryl H. Arrowsmith, Matthieu Schapira

published 19 Dec 2013

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Fluorescence Imaging-Based High-Throughput Screening of Fast- and Slow-Cycling LOV Proteins

Fuun Kawano, Yuki Aono, Hideyuki Suzuki, Moritoshi Sato

published 18 Dec 2013

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Membrane Interactions of S100A12 (Calgranulin C)

Assuero F. Garcia, José L. S. Lopes, Antonio J. Costa-Filho, Bonnie A. Wallace, Ana P. U. Araujo

published 18 Dec 2013

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Structural Analysis of Influenza A Virus Matrix Protein M1 and Its Self-Assemblies at Low pH

Eleonora V. Shtykova, Lyudmila A. Baratova, Natalia V. Fedorova, Victor A. Radyukhin, Alexander L. Ksenofontov, Vladimir V. Volkov, Alexander V. Shishkov, Alexey A. Dolgov, Liudmila A. Shilova, Oleg V. Batishchev, Cy M. Jeffries, Dmitri I. Svergun

published 16 Dec 2013

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