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Proteases

Amino acid T25 in the substrate-binding domain of SARS-CoV-2 nsp5 is involved in viral replication in the mouse lung

Yoshiro Sugiura, Kenta Shimizu, Tatsuki Takahashi, Shiori Ueno, Haruka Tanigou, Sodbayasgalan Amarbayasgalan, Wataru Kamitani

published 06 Dec 2024

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Evaluating the specificity of flavivirus proteases in Aedes aegypti cells for dengue virus 2-derived cleavage sites

Alexius O. Dingle, Zach N. Adelman

published 03 Dec 2024

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Motif mapping during chickpea germination reveals a complex sequential activation of different proteolytic activities

Indrani Bera, Michael O’Sullivan, Caitriona Scaife, Gerard Cagney, Denis C. Shields

published 31 Oct 2024

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High keratinase and other types of hydrolase activity of the new strain of Bacillus paralicheniformis

Saniya Aktayeva, Bekbolat Khassenov

published 25 Oct 2024

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Prolonging the circulatory half-life of C1 esterase inhibitor via albumin fusion

Sangavi Sivananthan, Varsha Bhakta, Negin Chaechi Tehrani, William P. Sheffield

published 23 Oct 2024

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Aging by autodigestion

Frank A. DeLano, Geert W. Schmid-Schönbein

published 17 Oct 2024

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Associations of circulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases with clinically relevant outcomes in idiopathic pulmonary fibrosis: Data from the IPF-PRO Registry

Olawale Amubieya, Jamie L. Todd, Megan L. Neely, Robert J. Kaner, Joseph A. Lasky, Andrew Namen, Christian Hesslinger, Scott M. Palmer, S. Samuel Weigt, John A. Belperio

published 17 Oct 2024

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Modelling the effects of 4-factor prothrombin complex concentrate for the management of factor Xa-associated bleeding

Ineke Muir, Eva Herzog, Markus Brechmann, Oliver Ghobrial, Alireza Rezvani Sharif, Maureane Hoffman

published 27 Sep 2024

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Alpha-fetoprotein and des-gamma-carboxy prothrombin can predict the objective response of patients with hepatocellular carcinoma receiving durvalumab plus tremelimumab therapy

Issei Saeki, Shigeo Shimose, Tetsu Tomonari, Takanori Ito, Joji Tani, Yasuto Takeuchi, Naoki Yoshioka, Takehito Naito, Mamiko Takeuchi, Satoru Kakizaki, Takeshi Hatanaka, Kyo Sasaki, Tetsuya Yasunaka, Masahiro Sakata, Hideki Iwamoto, Satoshi Itano, Tomotake Shirono, Norikazu Tanabe, Takafumi Yamamoto, Yuki Kanayama, Atsushi Naganuma, Sohji Nishina, Motoyuki Otsuka, Hideki Kobara, Hiroki Kawashima, Tetsuji Takayama, Takumi Kawaguchi, Takahiro Yamasaki, Taro Takami, Hepatology InVestigator Experts in Japan (HIVE-J) Study Group

published 25 Sep 2024

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Identification of critical amino acids in the DNA binding domain of LuxO: Lessons from a constitutive active LuxO

Shradha Surin, Richa Singh, Manpreet Kaur, Gourab Basu Choudhury, Himanshu Sen, Chetna Dureja, Saumen Datta, Saumya Raychaudhuri

published 17 Sep 2024

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Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines

Young Jun An, Ye-Eun Jung, Kyeong Won Lee, Prashant Kaushal, In Young Ko, Seung Min Shin, Sangho Ji, Wookyung Yu, Cheolju Lee, Won-Kyu Lee, Kiweon Cha, Jung-Hyun Lee, Sun-Shin Cha, Hyung-Soon Yim

published 05 Sep 2024

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Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

Estelle Ifrid, Hajer Ouertatani-Sakouhi, Hiba Zein El Dine, Tania Jauslin, Gianpaolo Chiriano, Leonardo Scapozza, Otmane Lamrabet, Pierre Cosson

published 26 Aug 2024

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Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients

Eiji Nakatani, Hiromitsu Ohno, Tatsunori Satoh, Daito Funaki, Chikara Ueki, Taku Matsunaga, Takayoshi Nagahama, Toru Tonoike, Hiromichi Yui, Akinori Miyakoshi, Yoshihiro Tanaka, Ataru Igarashi, Hiraku Kumamaru, Nagato Kuriyama, Akira Sugawara

published 09 Aug 2024

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