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Proteases

Associations of circulating matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases with clinically relevant outcomes in idiopathic pulmonary fibrosis: Data from the IPF-PRO Registry

Olawale Amubieya, Jamie L. Todd, Megan L. Neely, Robert J. Kaner, Joseph A. Lasky, Andrew Namen, Christian Hesslinger, Scott M. Palmer, S. Samuel Weigt, John A. Belperio

published 17 Oct 2024

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Modelling the effects of 4-factor prothrombin complex concentrate for the management of factor Xa-associated bleeding

Ineke Muir, Eva Herzog, Markus Brechmann, Oliver Ghobrial, Alireza Rezvani Sharif, Maureane Hoffman

published 27 Sep 2024

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Alpha-fetoprotein and des-gamma-carboxy prothrombin can predict the objective response of patients with hepatocellular carcinoma receiving durvalumab plus tremelimumab therapy

Issei Saeki, Shigeo Shimose, Tetsu Tomonari, Takanori Ito, Joji Tani, Yasuto Takeuchi, Naoki Yoshioka, Takehito Naito, Mamiko Takeuchi, Satoru Kakizaki, Takeshi Hatanaka, Kyo Sasaki, Tetsuya Yasunaka, Masahiro Sakata, Hideki Iwamoto, Satoshi Itano, Tomotake Shirono, Norikazu Tanabe, Takafumi Yamamoto, Yuki Kanayama, Atsushi Naganuma, Sohji Nishina, Motoyuki Otsuka, Hideki Kobara, Hiroki Kawashima, Tetsuji Takayama, Takumi Kawaguchi, Takahiro Yamasaki, Taro Takami, Hepatology InVestigator Experts in Japan (HIVE-J) Study Group

published 25 Sep 2024

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Identification of critical amino acids in the DNA binding domain of LuxO: Lessons from a constitutive active LuxO

Shradha Surin, Richa Singh, Manpreet Kaur, Gourab Basu Choudhury, Himanshu Sen, Chetna Dureja, Saumen Datta, Saumya Raychaudhuri

published 17 Sep 2024

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Structural and biochemical investigation into stable FGF2 mutants with novel mutation sites and hydrophobic replacements for surface-exposed cysteines

Young Jun An, Ye-Eun Jung, Kyeong Won Lee, Prashant Kaushal, In Young Ko, Seung Min Shin, Sangho Ji, Wookyung Yu, Cheolju Lee, Won-Kyu Lee, Kiweon Cha, Jung-Hyun Lee, Sun-Shin Cha, Hyung-Soon Yim

published 05 Sep 2024

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Compound K14 inhibits bacterial killing and protease activity in Dictyostelium discoideum phagosomes

Estelle Ifrid, Hajer Ouertatani-Sakouhi, Hiba Zein El Dine, Tania Jauslin, Gianpaolo Chiriano, Leonardo Scapozza, Otmane Lamrabet, Pierre Cosson

published 26 Aug 2024

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Comparing the effects of biguanides and dipeptidyl peptidase-4 inhibitors on cardio-cerebrovascular outcomes, nephropathy, retinopathy, neuropathy, and treatment costs in diabetic patients

Eiji Nakatani, Hiromitsu Ohno, Tatsunori Satoh, Daito Funaki, Chikara Ueki, Taku Matsunaga, Takayoshi Nagahama, Toru Tonoike, Hiromichi Yui, Akinori Miyakoshi, Yoshihiro Tanaka, Ataru Igarashi, Hiraku Kumamaru, Nagato Kuriyama, Akira Sugawara

published 09 Aug 2024

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Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations

Shahid Ullah, Farhan Ullah, Wajeeha Rahman, Anees Ullah, Sultan Haider, Cao Yueguang

published 08 Aug 2024

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Ascorbic acid as serine protease inhibitor in lung cancer cell line and human serum albumin

Bijon Kumar Sil, Mohd. Raeed Jamiruddin, Pijush Kumar Paul, Nattanit Aekwattanaphol, Titpawan Nakpheng, Md. Ahsanul Haq, Wilaiporn Buatong, Teerapol Srichana

published 23 Jul 2024

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Diagnostic ability of Peptidase S8 gene in the Arthrodermataceae causing dermatophytoses: A metadata analysis

Apoorva R. Kenjar, Juliet Roshini Mohan Raj, Banavasi Shanmukha Girisha, Indrani Karunasagar

published 09 Jul 2024

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Expression and purification of human neutrophil proteinase 3 from insect cells and characterization of ligand binding

Fahimeh Khorsand, Bengt Erik Haug, Inari Kursula, Nathalie Reuter, Ruth Brenk

published 25 Jun 2024

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LSTM-driven drug design using SELFIES for target-focused de novo generation of HIV-1 protease inhibitor candidates for AIDS treatment

M. Taleb Albrijawi, Reda Alhajj

published 21 Jun 2024

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Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization

Yasuhiko Matsumoto, Eri Sato, Takashi Sugita

published 30 May 2024

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