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Point mutation

The impact of mutations on TP53 protein and MicroRNA expression in HNSCC: Novel insights for diagnostic and therapeutic strategies

Ashraf Attia Mahmoud, Mohd Firdaus Raih, Edison Eukun Sage, Qurashi M. Ali, Omnia H. Suliman, Sabah A. E. Ibrahim, Osama Mohamed, Samar Abdelrazeg, Sofia B. Mohamed

published 07 May 2025

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CRISPR genome editing using a combined positive and negative selection system

Ishrya Sharma, Kerisa Hall, Shannon Moonah

published 06 May 2025

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Epidemiological and spatial analysis of newly diagnosed HIV-1/AIDS patients before antiretroviral therapy in Ningxia from 2020 to 2021

Yichang Liu, Xiaofa Ma, Jianxin Pei, Dongzhi Yang, Yufeng Li, Xiaohong Zhu, Zhonglan Wu

published 22 Apr 2025

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Gama rays mediated improvement of catalytic efficiency and thermostability of glucoamylase by replacing active site leucine to isoleucene from super koji (Aspergillus oryzae)

Anam Saqib, Saif -ur-Rehman, Hazrat Ali, Noor Hassan, Asad Ali, Muhammad Hamid Rashid

published 18 Apr 2025

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Mis-splicing drives loss of function of p53^E224D point mutation

Ian C. Lock, Nathan H. Leisenring, Warren Floyd, Eric S. Xu, Lixia Luo, Yan Ma, Erin C. Mansell, Diana M. Cardona, Chang-Lung Lee, David G. Kirsch

published 05 Mar 2025

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Inhibition of the anti-apoptotic protein BCL2 in EML4-ALK cell models as a second proposed therapeutic target for non-small cell lung cancer

Richard Junior Zapata Dongo, Diletta Fontana, Luca Mologni, Juan Enrique Faya Castillo, Stefany Fiorella Infante Varillas

published 21 Jan 2025

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Whole-genome resequencing reveals collagen-related genes in Kele pigs

Yu Dan Zhang, Wei Yuan, Huan Bi, Xiao Yang, Yi Yu Zhang, Wei Chen

published 31 Dec 2024

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Genomic assessment of targets implicated in Rhipicephalus microplus acaricide resistance

Christina Meiring, Michel Labuschagne

published 05 Dec 2024

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Complete genome sequencing of SARS-CoV-2 strains that were circulating in Uzbekistan over the course of four pandemic waves

Gulnoza Esonova, Abrorjon Abdurakhimov, Shakhnoza Ibragimova, Diyora Kurmaeva, Jakhongirbek Gulomov, Doniyor Mirazimov, Khonsuluv Sohibnazarova, Alisher Abdullaev, Shahlo Turdikulova, Dilbar Dalimova

published 19 Nov 2024

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Clinical and molecular characteristics associated with high PD-L1 expression in EGFR-mutated lung adenocarcinoma

Jeremy Slomka, Hugo Berthou, Audrey Mansuet-Lupo, Hélène Blons, Elizabeth Fabre, Ivan Lerner, Bastien Rance, Marco Alifano, Jeanne Chapron, Gary Birsen, Laure Gibault, Jennifer Arrondeau, Karen Leroy, Marie Wislez

published 07 Nov 2024

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Overcoming problematic growth phenotypes in organoids from patients with monogenic GI disease

Katlynn Bugda Gwilt, Jay R. Thiagarajah

published 04 Nov 2024

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Bioinformatics design of peptide binding to the human cardiac troponin I (cTnI) in biosensor development for myocardial infarction diagnosis

Muhammad Miftah Jauhar, Filasta Rachel Damairetha, Etik Mardliyati, Mokhamad Fakhrul Ulum, Putri Hawa Syaifie, Fahmi Fahmi, Ardianto Satriawan, Wervyan Shalannanda, Isa Anshori

published 22 Oct 2024

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Elucidating the role of MLL1 nsSNPs: Structural and functional alterations and their contribution to leukemia development

Hakeemah H. Al-nakhle, Hind S. Yagoub, Rahaf Y. Alrehaili, Ola A. Shaqroon, Minna K. Khan, Ghaidaa S. Alsharif

published 15 Oct 2024

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