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Point mutation

Improved transformation efficiency of group A Streptococcus by inactivation of a type I restriction modification system

Meredith B. Finn, Kathryn M. Ramsey, Hunter J. Tolliver, Simon L. Dove, Michael R. Wessels

published 29 Apr 2021

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Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

Debra Van Egeren, Alexander Novokhodko, Madison Stoddard, Uyen Tran, Bruce Zetter, Michael Rogers, Bradley L. Pentelute, Jonathan M. Carlson, Mark Hixon, Diane Joseph-McCarthy, Arijit Chakravarty

published 28 Apr 2021

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Lack of collagen α6(IV) chain in mice does not cause severe-to-profound hearing loss or cochlear malformation, a distinct phenotype from nonsyndromic hearing loss with COL4A6 missense mutation

Shaoying Tang, Tomoko Yonezawa, Yukihide Maeda, Mitsuaki Ono, Takahiro Maeba, Toru Miyoshi, Ryusuke Momota, Yasuko Tomono, Toshitaka Oohashi

published 13 Apr 2021

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Identifying treatment options for BRAF^V600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial

Patricia M. LoRusso, Aleksandar Sekulic, Jeffrey A. Sosman, Winnie S. Liang, John Carpten, David W. Craig, David B. Solit, Alan H. Bryce, Jeffrey A. Kiefer, Jessica Aldrich, Sara Nasser, Rebecca Halperin, Sara A. Byron, Mary Jo Pilat, Scott A. Boerner, Diane Durecki, William P. D. Hendricks, Daniel Enriquez, Tyler Izatt, Jonathan Keats, Christophe Legendre, Svetomir N. Markovic, Amy Weise, Fatima Naveed, Jessica Schmidt, Gargi D. Basu, Shobana Sekar, Jonathan Adkins, Erica Tassone, Karthigayini Sivaprakasam, Victoria Zismann, Valerie S. Calvert, Emanuel F. Petricoin, Leslie Anne Fecher, Christopher Lao, J. Paul Eder, Nicholas J. Vogelzang, Jane Perlmutter, Mark Gorman, Barbara Manica, Lisa Fox, Nicholas Schork, Daniel Zelterman, Michelle DeVeaux, Richard W. Joseph, C. Lance Cowey, Jeffrey M. Trent

published 07 Apr 2021

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Epidemiological and clinical burden of EGFR Exon 20 insertion in advanced non-small cell lung cancer: A systematic literature review

Heather Burnett, Helena Emich, Chris Carroll, Naomi Stapleton, Parthiv Mahadevia, Tracy Li

published 08 Mar 2021

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Deuterium-depletion has no significant impact on the mutation rate of Escherichia coli, deuterium abundance therefore has a probabilistic, not deterministic effect on spontaneous mutagenesis

Walliyulahi Ajibola, Ildikó Karcagi, Gábor Somlyai, Ildikó Somlyai, Tamás Fehér

published 08 Mar 2021

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Antimicrobial resistance and interspecies gene transfer in Campylobacter coli and Campylobacter jejuni isolated from food animals, poultry processing, and retail meat in North Carolina, 2018–2019

Dawn M. Hull, Erin Harrell, Arnoud H. M. van Vliet, Maria Correa, Siddhartha Thakur

published 11 Feb 2021

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Molecular characterization and the mutation pattern of SARS-CoV-2 during first and second wave outbreaks in Hiroshima, Japan

Ko Ko, Shintaro Nagashima, Bunthen E., Serge Ouoba, Tomoyuki Akita, Aya Sugiyama, Masayuki Ohisa, Takemasa Sakaguchi, Hidetoshi Tahara, Hiroki Ohge, Hideki Ohdan, Tatsuhiko Kubo, Eisaku Kishita, Masao Kuwabara, Kazuaki Takahashi, Junko Tanaka

published 05 Feb 2021

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Single nucleotide polymorphism leads to daptomycin resistance causing amino acid substitution—T345I in MprF of clinically isolated MRSA strains

Masaki Nakamura, Hayato Kawada, Hiroki Uchida, Yusuke Takagi, Shuichi Obata, Ryotaro Eda, Hideaki Hanaki, Hidero Kitasato

published 22 Jan 2021

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In silico comparative genomics of SARS-CoV-2 to determine the source and diversity of the pathogen in Bangladesh

Tushar Ahmed Shishir, Iftekhar Bin Naser, Shah M. Faruque

published 20 Jan 2021

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CYP450 core involvement in multiple resistance strains of Aedes aegypti from French Guiana highlighted by proteomics, molecular and biochemical studies

Yanouk Epelboin, Lanjiao Wang, Quentin Giai Gianetto, Valérie Choumet, Pascal Gaborit, Jean Issaly, Amandine Guidez, Thibaut Douché, Thibault Chaze, Mariette Matondo, Isabelle Dusfour

published 11 Jan 2021

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DACH1 mutation frequency in endometrial cancer is associated with high tumor mutation burden

McKayla J. Riggs, Nan Lin, Chi Wang, Dava W. Piecoro, Rachel W. Miller, Oliver A. Hampton, Mahadev Rao, Frederick R. Ueland, Jill M. Kolesar

published 30 Dec 2020

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In vitro and in vivo characterization of Recifercept, a soluble fibroblast growth factor receptor 3, as treatment for achondroplasia

Diogo Gonçalves, Guylène Rignol, Pierre Dellugat, Guido Hartmann, Stephanie Sarrazy Garcia, Jeffrey Stavenhagen, Luca Santarelli, Elvire Gouze, Christian Czech

published 28 Dec 2020

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