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Osteoclasts

A composite docking approach for the identification and characterization of ectosteric inhibitors of cathepsin K

Simon Law, Preety Panwar, Jody Li, Adeleke H. Aguda, Andrew Jamroz, Rafael V. C. Guido, Dieter Brömme

published 31 Oct 2017

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Protective effect of low-dose risedronate against osteocyte apoptosis and bone loss in ovariectomized rats

Tingjun Ye, Peng Cao, Jin Qi, Qi Zhou, D. Sudhaker Rao, Shijing Qiu

published 18 Oct 2017

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Salt-inducible kinases (SIK) inhibition reduces RANKL-induced osteoclastogenesis

Maria Stella Lombardi, Corine Gilliéron, Majoska Berkelaar, Cem Gabay

published 03 Oct 2017

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Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions

Kelly Aukes, Cynthia Forsman, Nicholas J. Brady, Kristina Astleford, Nicholas Blixt, Deepali Sachdev, Eric D. Jensen, Kim C. Mansky, Kathryn L. Schwertfeger

published 02 Oct 2017

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Class II and IV HDACs function as inhibitors of osteoclast differentiation

Nicholas C. Blixt, Bora K. Faulkner, Kristina Astleford, Rosemary Lelich, Jacob Schering, Ekaterina Spencer, Rajaram Gopalakrishnan, Eric D. Jensen, Kim C. Mansky

published 27 Sep 2017

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SIRT1 is a positive regulator of in vivo bone mass and a therapeutic target for osteoporosis

Kayvan Zainabadi, Cassie J. Liu, Alison L. M. Caldwell, Leonard Guarente

published 22 Sep 2017

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Treatment of OPG-deficient mice with WP9QY, a RANKL-binding peptide, recovers alveolar bone loss by suppressing osteoclastogenesis and enhancing osteoblastogenesis

Yuki Ozaki, Masanori Koide, Yuriko Furuya, Tadashi Ninomiya, Hisataka Yasuda, Midori Nakamura, Yasuhiro Kobayashi, Naoyuki Takahashi, Nobuo Yoshinari, Nobuyuki Udagawa

published 22 Sep 2017

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Effects of metformin on inflammation, oxidative stress, and bone loss in a rat model of periodontitis

Aurigena Antunes de Araújo, Aline de Sousa Barbosa Freitas Pereira, Caroline Addison Carvalho Xavier de Medeiros, Gerly Anne de Castro Brito, Renata Ferreira de Carvalho Leitão, Lorena de Souza Araújo, Paulo Marcos Matta Guedes, Sarah Hiyari, Flávia Q. Pirih, Raimundo Fernandes de Araújo Júnior

published 28 Aug 2017

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Osteoclastic differentiation and resorption is modulated by bioactive metal ions Co²⁺, Cu²⁺ and Cr³⁺ incorporated into calcium phosphate bone cements

Anne Bernhardt, Martha Schamel, Uwe Gbureck, Michael Gelinsky

published 01 Aug 2017

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A Jak1/2 inhibitor, baricitinib, inhibits osteoclastogenesis by suppressing RANKL expression in osteoblasts in vitro

Kohei Murakami, Yasuhiro Kobayashi, Shunsuke Uehara, Takako Suzuki, Masanori Koide, Teruhito Yamashita, Midori Nakamura, Naoyuki Takahashi, Hiroyuki Kato, Nobuyuki Udagawa, Yukio Nakamura

published 14 Jul 2017

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MicroRNA-433-3p promotes osteoblast differentiation through targeting DKK1 expression

Xiaolin Tang, Jiantao Lin, Guanhai Wang, Jianlin Lu

published 19 Jun 2017

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Osteoblast-specific overexpression of complement receptor C5aR1 impairs fracture healing

Stephanie Bergdolt, Anna Kovtun, Yvonne Hägele, Astrid Liedert, Thorsten Schinke, Michael Amling, Markus Huber-Lang, Anita Ignatius

published 14 Jun 2017

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Zoledronate suppressed angiogenesis and osteogenesis by inhibiting osteoclasts formation and secretion of PDGF-BB

Si-yong Gao, Guang-sen Zheng, Lin Wang, Yu-jie Liang, Si-en Zhang, Xiao-mei Lao, Kan Li, Gui-qing Liao

published 08 Jun 2017

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