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Mouse models

Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice

Julie Rose Hens, Stacey Brown, Pawel Licznerski, Jacqueline Suarez, Elizabeth Jonas, John J. Wysolmerski

published 15 Dec 2025

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Impact of rAAV-shRNA treatment targeting mechanosensitive Ilk1 and Fermt2 in a mouse model of sepsis-induced muscle weakness

Alexander Pacolet, Inge Derese, Lies Pauwels, Sarah Vander Perre, Maxime Smits, Chris Van den Haute, Sarah Derde, Katrien Koppo, Rik Gijsbers, Lies Langouche

published 12 Dec 2025

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UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury

Dongliang Liu, Yudong Liu, Tianding Wu, Jianzhong Hu

published 12 Dec 2025

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Butyrate ameliorates DSS-induced ulcerative colitis in mice by facilitating autophagy in intestinal epithelial cells and modulating the gut microbiota through blocking the PI3K-AKT-mTOR pathway

Ruifang Li, Yan Sun, Drolma Kelsang, Mingzhi Feng, Hanhui Cai, Jun Zhang

published 11 Dec 2025

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A mouse model of early sporadic tau pathology induces neurogenic plasticity in the hippocampus

Alyssa M. Ash, Sue Rim Baek, Peyton Holder, Sara Singh, Nicholas P. Vyleta, Matthew Willman, Kevin R. Nash, Jason S. Snyder

published 10 Dec 2025

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Human-derived fecal virome transplantation (FVT) reshapes the murine gut microbiota and virome, enhancing glucose regulation

Melany Cervantes-Echeverría, Marco Antonio Jimenez-Rico, Rubiceli Manzo, Abigail Hernández-Reyna, Fernanda Cornejo-Granados, Shirley Bikel, Víctor González, Juan Manuel Hurtado Ramírez, Filiberto Sánchez-López, Jonathan Salazar-León, Gustavo Pedraza-Alva, Leonor Perez-Martinez, Adrian Ochoa-Leyva

published 05 Dec 2025

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Co-regulation of microglial subgroups in Alzheimer’s amyloid pathology: Implications for diagnosis and drug development

Yu Zhou, Yukuan Huang, Yangchang Fan, Feng Xue

published 05 Dec 2025

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The rsmA mutant from Pseudomonas aeruginosa ID4365 is a non-virulent strain that is suitable for pyocyanin and phenazine-1-carboxylic acid production

Misael Josafat Fabian Del-Olmo, Luis Fernando Montelongo-Martínez, Gisela Viridiana Villafañe-Barajas, Abigail González-Valdez, Veronica Roxana Flores-Vega, Roberto Rosales-Reyes, Marco Elias Gudiño-Zayas, Thelma Rizo-Pica, Raunel Tinoco-Valencia, Adelfo Escalante, Gloria Soberón-Chávez, Miguel Cocotl-Yañez

published 04 Dec 2025

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Human umbilical cord-derived mesenchymal stem cells alleviate autoimmune hepatitis by inhibiting hepatic ferroptosis

Yaqin Li, Bing Liu, Guoxin Hu, Tao Zhou, Xuanqiu He, Ling Guo, Luoshi Zhang, Weizhao Tong, Yihua Chen, Youhua Xu, Guangdong Tong, Wei V. Zheng

published 04 Dec 2025

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Determination of appropriate time for establishing a model of postmenopausal osteoporosis induced by bilateral oophorectomy: From bibliometric analysis to animal experiment

Yan She, Linyu Yin, Yijin Kuang, Yujing Zhou, Dandan Zhou, Xian Tang, Shanxi Wang, Songtao Liu, Kun Ai

published 04 Dec 2025

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Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, Sonia Bustamante, Krishan Gondal, Peggy Rentsch, Gayathri Sundaram, Michael D. Lovelace, Bryce Vissel, Bruce J. Brew

published 04 Dec 2025

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Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis

Yao-Yao Mao, Ke Zhang, Dan-Dan Zhao, Jia-Wei Cui, Zhan-Dong Lin, Cong-Yue Zhang, Yue-Min Nan

published 26 Nov 2025

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Dietary fiber inulin mitigates peripheral neuropathy in different stages of diabetes via modulating gut microbiota and metabolites in db/db mice

Ke Li, Wenjun Fu, Yuanyuan Liu, Jing Xue, Xiaoli Yang, Leiwen Wang, Jin Xu, Junbai Ma, Rong Su, Xia Yang, Yuning Sun, Hao Wang

published 20 Nov 2025

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