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Mouse models

A new investigation of nonalcoholic fatty liver disease: Effects of hypoxia on mitochondrial function and lipid droplet autophagy

Meiyuan Tian, Yaogang Zhang, Zhe Liu, Na Zhao, Dengliang Huang, Jing Hou, Li Sun, Yuan Jiang, Guangcun Zhang, Yanyan Ma

published 25 Sep 2025

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A new external jugular venipuncture technique for efficient vascular access that exploits a murine anatomical variation

Suguru Yamauchi, Andrei Gurau, Kaitlyn Ecoff, Kristen P. Rodgers, Yuping Mei, Frank Bosmans, Franck Housseau, Yun Chen, John Michel, Andreas S. Barth, Jinny S. Ha, Takumi Iwasawa, Kazunori Kato, Ryohma Tsuchiya, Miki Yamauchi, Hajime Orita, Shinji Mine, Tetsu Fukunaga, Malcolm V. Brock

published 25 Sep 2025

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IGF-1 downregulates matrix metalloproteinase 8 to promote plaque stability: Evidence from myeloid cell-specific MMP8 in atherosclerosis

Patricia Snarski, Sergiy Sukhanov, Tadashi Yoshida, Svitlana Danchuk, Andrew Gross, Fareed Sindi, Vikara Rivera-Lopez, Patrice Delafontaine, Yusuke Higashi

published 24 Sep 2025

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Identification of coexisting Mfrp^rd6 and Pde6b^rd10 mutations causing spontaneous retinal detachment in commercially available rd6 mice

Asaka Lee Shiozawa, Maika Hosoi Kobayashi, Yusuke Shiozawa, Yasuhiro Ikeda, Yoshitaka Miyagawa, Fumiki Okamoto, Mashito Sakai, Takashi Okada, Tsutomu Igarashi

published 23 Sep 2025

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Distinct transcriptomic effects of intermittent and chronic caloric restriction in mammary fat pad of a breast cancer mouse model

Bilge Guvenc Tuna, Nazim Arda Keles, Munevver Burcu Cicekdal, Soner Dogan, Sulev Koks

published 23 Sep 2025

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Active electroceutical treatment of Pseudomonas aeruginosa infected murine wounds

Colin R. Mack, Traci A. Wilgus, Sheri Dellos-Nolan, Tony DiCesare, Daria Bentley, Fraser J. Daniel, Vish V. Subramaniam, Sahil Mahajan, Paul Stoodley, Daniel J. Wozniak, Shaurya Prakash

published 22 Sep 2025

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High-resolution ex vivo nanoCT reveals 3D architecture of the adult male mouse lower urogenital tract

Ajinkya R. Limkar, Simran M. Sharma, William A. Ricke

published 18 Sep 2025

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Pre-infection cerebral cortex structure predicts murine sepsis outcome

Robert M. Gallant, Shahinur Alam, Krishnan Venkataraman, Benjamin S. McKenna, Khaled Khairy, Janelle S. Ayres

published 17 Sep 2025

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Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C. de Faria, Hemant K. Bid, David Koller, Lucia Casadei, Katherine J. Ladner, David Wang, Valerie Grignol, O. Hans Iwenofu, Dawn Chandler, Denis C. Guttridge, Raphael E. Pollock

published 17 Sep 2025

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Optimized processing of Gardenia Fruits with ginger juice: Unveiling therapeutic mechanisms for cholestatic liver injury through TLR4/NF-κB, FXR/PPAR-α, and PI3K/AKT/GSK-3β

Chenzi Lyu, Xianglong Meng, Juan Wang, Haifeng Shao, Yang Wang, Yong-Ki Park, Shuosheng Zhang, Hyo Won Jung

published 16 Sep 2025

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KYLO-0603, a novel liver-targeting, thyroid hormone receptor-β agonist for the inhibition of MASH progression

Xueqin lu, Shengjun Wang, Yanchun Du, Bixian Xie, Qingyan Chen, Jinzhen Lin, Bailing Chen, Kunyuan Cui

published 15 Sep 2025

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ACE1 does not influence cerebral Aβ degradation or amyloid plaque accumulation in 5XFAD mice

Sohee Jeon, Alia O. Alia, Jelena Popovic, Robert Vassar, Leah K. Cuddy

published 15 Sep 2025

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Validation of the FVB/N-Tg(HSA* LR)20bCath mice of myotonic dystrophy using swallowing function assessment, histology, and immunofluorescence analysis

Rie Asayama, Kaori Tanaka-Nishikubo, Jun Iwanami, Takahiro Fukazawa, Motoi Kanagawa, Naohito Hato

published 12 Sep 2025

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