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Mouse models

Renal and hepatic function is preserved following inducible knockout of kynurenine pathway enzymes KMO or QPRT in adult mice

Benjamin S. Summers, Luke Milham, Sonia Bustamante, Krishan Gondal, Peggy Rentsch, Gayathri Sundaram, Michael D. Lovelace, Bryce Vissel, Bruce J. Brew

published 04 Dec 2025

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Combining transcriptomics with network pharmacology to explore the mechanism of Yiqi Huoxue decoction against liver fibrosis

Yao-Yao Mao, Ke Zhang, Dan-Dan Zhao, Jia-Wei Cui, Zhan-Dong Lin, Cong-Yue Zhang, Yue-Min Nan

published 26 Nov 2025

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Dietary fiber inulin mitigates peripheral neuropathy in different stages of diabetes via modulating gut microbiota and metabolites in db/db mice

Ke Li, Wenjun Fu, Yuanyuan Liu, Jing Xue, Xiaoli Yang, Leiwen Wang, Jin Xu, Junbai Ma, Rong Su, Xia Yang, Yuning Sun, Hao Wang

published 20 Nov 2025

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Dysbiosis of gut microbiota in C57BL/6-Lep^em1hwl/Korl mice during microplastics-caused hepatic metabolism disruption

Yu Sang Choi, Yu Jeong Roh, Ji Eun Kim, Hee Jin Song, Ayun Seol, Su Jeong Lim, Su Ha Wang, Ji Eun Sung, Ye Eun Ryu, Ye Ryeong Kim, Hyun Su Park, Hong Joo Son, Yu Jin Kim, Eun Sang Jung, Sunho Park, Dae Youn Hwang

published 20 Nov 2025

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Effects of ascorbic acid on intestinal flora and metabolites of C57 mice exposed to formaldehyde in digestive tract

Xin Ling, Ziyan Hao, Yixuan Shi, Yuting Li, Kehan Wang, Yunshan Zhang, Yue Wang

published 19 Nov 2025

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TSLPR deficiency attenuates AHR independently of eosinophilia and mucus secretion in a chronic HDM mouse model of allergic asthma

Latifa Koussih, Sina Taefehshokr, Lianyu Shan, Sujata Basu, Andrew Halayko, Bouchaib Lamkhioued, Abdelilah S. Gounni

published 19 Nov 2025

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In vivo investigation of STN1 downregulation in melanoma formation in adult mice following UV irradiation

Sara Knowles, Fang Wang, Maarten C. Bosland, Shobhan Gaddameedhi, Weihang Chai

published 14 Nov 2025

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Repeated application of transcranial ultrasound maintains spatial and recognition memory in 5xFAD mice with reduction of amyloid-β burden

Seung-Schik Yoo, Anvita Reddy, William Carroll, Kanyapat Ploypradith

published 12 Nov 2025

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PIM1 induces hypoxia-related fibroblast senescence in a mouse model of stress urinary incontinence

Ya Xiao, Mao Chen, Lingyun Li, Liying Chen, Xiaoyu Tian, Xiaoyu Huang, Fangyi Zhu, Bingshu Li, Li Hong

published 12 Nov 2025

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Behavioral analyses of a forebrain glutamatergic neuron specific Ywhae conditional knockout mouse model

Meaghan Navarrete-Mathews, Gloria S. Lee, Angel Walerio, Dylan Horne, Yuying Wu, Yi Zhou

published 11 Nov 2025

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Skin melanin is associated with body temperature regulation in humans and mice

Kale S. Bongers, Santiago Tovar, Zanthia Wiley, Michele Sumler, Nina G. Jablonski, Adewole S. Adamson, Sivasubramanium V. Bhavani

published 07 Nov 2025

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Xiao Qing Long Tang ameliorates neutrophil extracellular trap-dendritic cells-T helper 17 cell axis in Neutrophilic Asthma

Xiaoying Ji, Hongda Chen, Sheng-dong He, Min Huang, Xiaoli You, Chuan Xiao, Zhifeng Chen, Jinwen Cai

published 06 Nov 2025

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Mature tau pathology is not improved by interfering with interleukin-1 receptor signaling in two mouse models of tauopathy

Dylan J. Finneran, Brianna M. Jackman, Taylor Desjarlais, Alayna Henry, Ahlam S. Soliman, Patricia C. Muskus, Rama Shankar, Bin Chen, Kevin R. Nash, Dave Morgan, Marcia N. Gordon

published 05 Nov 2025

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