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Mouse models

The Antidiabetic Drug Ciglitazone Induces High Grade Bladder Cancer Cells Apoptosis through the Up-Regulation of TRAIL

Marie-Laure Plissonnier, Sylvie Fauconnet, Hugues Bittard, Isabelle Lascombe

published 12 Dec 2011

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Macrophage LRP1 Suppresses Neo-Intima Formation during Vascular Remodeling by Modulating the TGF-β Signaling Pathway

Selen Catania Muratoglu, Shani Belgrave, Anna P. Lillis, Mary Migliorini, Susan Robinson, Elizabeth Smith, Li Zhang, Dudley K. Strickland

published 09 Dec 2011

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Actin Nemaline Myopathy Mouse Reproduces Disease, Suggests Other Actin Disease Phenotypes and Provides Cautionary Note on Muscle Transgene Expression

Gianina Ravenscroft, Connie Jackaman, Caroline A. Sewry, Elyshia McNamara, Sarah E. Squire, Allyson C. Potter, John Papadimitriou, Lisa M. Griffiths, Anthony J. Bakker, Kay E. Davies, Nigel G. Laing, Kristen J. Nowak

published 09 Dec 2011

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Rapamycin Combined with Anti-CD45RB mAb and IL-10 or with G-CSF Induces Tolerance in a Stringent Mouse Model of Islet Transplantation

Nicola Gagliani, Silvia Gregori, Tatiana Jofra, Andrea Valle, Angela Stabilini, David M. Rothstein, Mark Atkinson, Maria Grazia Roncarolo, Manuela Battaglia

published 09 Dec 2011

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Adeno-Associated Virus-Mediated Rescue of the Cognitive Defects in a Mouse Model for Angelman Syndrome

Jennifer L. Daily, Kevin Nash, Umesh Jinwal, Todd Golde, Justin Rogers, Melinda M. Peters, Rebecca D. Burdine, Chad Dickey, Jessica L. Banko, Edwin J. Weeber

published 09 Dec 2011

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Skeletal Muscle-Specific Expression of PGC-1α-b, an Exercise-Responsive Isoform, Increases Exercise Capacity and Peak Oxygen Uptake

Miki Tadaishi, Shinji Miura, Yuko Kai, Yutaka Kano, Yuichi Oishi, Osamu Ezaki

published 08 Dec 2011

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Tau-Targeted Immunization Impedes Progression of Neurofibrillary Histopathology in Aged P301L Tau Transgenic Mice

Mian Bi, Arne Ittner, Yazi D. Ke, Jürgen Götz, Lars M. Ittner

published 08 Dec 2011

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Impact of the Lectin Chaperone Calnexin on the Stress Response, Virulence and Proteolytic Secretome of the Fungal Pathogen Aspergillus fumigatus

Margaret V. Powers-Fletcher, Kalyani Jambunathan, Jordan L. Brewer, Karthik Krishnan, Xizhi Feng, Amit K. Galande, David S. Askew

published 07 Dec 2011

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Onset and Progression of Behavioral and Molecular Phenotypes in a Novel Congenic R6/2 Line Exhibiting Intergenerational CAG Repeat Stability

Randi-Michelle Cowin, Nghiem Bui, Deanna Graham, Jennie R. Green, Stephan Grueninger, Lisa A. Yuva-Paylor, Arsalan U. Syed, Andreas Weiss, Richard Paylor

published 07 Dec 2011

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Role of NADPH Oxidase versus Neutrophil Proteases in Antimicrobial Host Defense

R. Robert Vethanayagam, Nikolaos G. Almyroudis, Melissa J. Grimm, David C. Lewandowski, Christine T. N. Pham, Timothy S. Blackwell, Ruta Petraitiene, Vidmantas Petraitis, Thomas J. Walsh, Constantin F. Urban, Brahm H. Segal

published 07 Dec 2011

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Redistribution of DAT/α-Synuclein Complexes Visualized by “In Situ” Proximity Ligation Assay in Transgenic Mice Modelling Early Parkinson's Disease

Arianna Bellucci, Laura Navarria, Elisa Falarti, Michela Zaltieri, Federica Bono, Ginetta Collo, Maria Grazia, Cristina Missale, PierFranco Spano

published 07 Dec 2011

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Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages

Jonathan E. Feig, Yueting Shang, Noemi Rotllan, Yuliya Vengrenyuk, Chaowei Wu, Raanan Shamir, Ines Pineda Torra, Carlos Fernandez-Hernando, Edward A. Fisher, Michael J. Garabedian

published 06 Dec 2011

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IL-1α/IL-1R1 Expression in Chronic Obstructive Pulmonary Disease and Mechanistic Relevance to Smoke-Induced Neutrophilia in Mice

Fernando M. Botelho, Carla M. T. Bauer, Donna Finch, Jake K. Nikota, Caleb C. J. Zavitz, Ashling Kelly, Kristen N. Lambert, Sian Piper, Martyn L. Foster, James J. P. Goldring, Jadwiga A. Wedzicha, Jennifer Bassett, Jonathan Bramson, Yoichiro Iwakura, Matthew Sleeman, Roland Kolbeck, Anthony J. Coyle, Alison A. Humbles, Martin R. Stämpfli

published 06 Dec 2011

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