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Mouse models

Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen

published 20 Apr 2026

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Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, Amy Strickland, Amber R. Hackett, Yurie Sato-Yamada, Xianrong Mao, Yo Sasaki, Jeffrey Milbrandt, A. Joseph Bloom, Aaron DiAntonio

published 17 Apr 2026

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MMP-2 associated imbalance of VEGF/Endostatin is linked to suppression of the PI3K/AKT/HIF-1α pathway in steroid-induced osteonecrosis of femoral head

Guangyang Zhang, Zhaopu Jing, Jialin Liang, Leifeng Lv, Xiaoqian Dang, Qichun Song

published 17 Apr 2026

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PDGFRα-positive mesenchymal stem/stromal cells contribute to autonomous vascular formation through in-body tissue architecture

Satoru Morikawa, Masaki Yoda, Takehito Ouchi, Takazumi Yasui, Kazumasa Fukuda, Michiru Sugimoto, Rintaro Harada, Tatsuaki Matsumoto, Yo Mabuchi, Osahiko Tsuji, Narihito Nagoshi, Yoshitaka Kase, Hideyuki Okano, Yuko Kitagawa, Masaya Nakamura, Taneaki Nakagawa, Yasuhide Nakayama

published 16 Apr 2026

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Impaired dynein function preserves spinal interneuron survival and positioning in an ALS-like mouse model

Eleni Christoforidou, Jordan S. Rowe, Fabio A. Simoes, Raphaelle Cassel, Luc Dupuis, Peter Nigel Leigh, Majid Hafezparast

published 02 Apr 2026

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Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation

Mariana Moraes de Lima Perini, Alyssa F. Fayemi, Julie N. Pugh, Elizabeth M. Scott, Karan Bhula, Austin Chirgwin, Olivia N. White, Nicolas F. Berbari, Jiliang Li

published 02 Apr 2026

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A phosphorous-based dendrimer targets mitochondria and normalizes the keratinocyte proliferation/differentiation balance to improve psoriasis

Emily Clement, Ranime Jebbawi, Abdelouahd Oukhrib, Hélène Labie, Maëlys Le Moal, Séverine Fruchon, Stéphanie Cassel, Anne-Marie Caminade, Cédric-Olivier Turrin, Muriel Blanzat, Michel Simon, Rémy Poupot

published 31 Mar 2026

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A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features

Jean-Pierre Bayley, Heggert G. Rebel, Peter Devilee

published 31 Mar 2026

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5-HT1B receptor agonists promote Schwann cell myelination

Yuka Kobayashi-Ujiie, Keiko Hiraki-Kamon, Shuji Wakatsuki, Toshiyuki Araki

published 27 Mar 2026

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STING pathway contributes to Steroid-Hyporesponsive Lung Inflammation in DSS-induced colitis mice model

Mariam Wed Eladham, Narjes Saheb Sharif-Askari, Bushra Mdkhana, Shirin Ali, Baraa Khalid Salah Al-Sheakly, Nival Ali, Balachandar Selvakumar, Fatemeh Saheb Sharif-Askari, Ibrahim Hachim, Rabih Halwani

published 27 Mar 2026

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APOE4 and doxorubicin impair inhibitory interneuron function and homeostatic regulation in the entorhinal cortex

Nancy Luo, Harshul Pandit, Shreya Kalra, Erin Tran, Jeanne Mandelblatt, Stefano Vicini, G. William Rebeck

published 26 Mar 2026

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Inhibition of transient receptor potential vanilloid 1 (TRPV1) by a novel selective antagonist for anti-nociceptive effect on inflammatory pain without hyperthermia

Jialiang Guan, Chenru Zhao, Qiqi Zhou, Chao Zhu

published 25 Mar 2026

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M₅ positive allosteric modulation alleviates parkinsonian motor deficits

Nicole E. Chambers, Dominic Hall, Morgan Kaplan, Sarah Garan, Tyler Eichner, Mark S. Moehle

published 25 Mar 2026

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