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Mouse models

Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis

Zhongyang Lu, Yanchun Li, Ai-Jun Li, Wing-Kin Syn, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang

published 04 Nov 2022

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All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity

Jafar S. Hasbullah, Erika N. Scott, Amit P. Bhavsar, Erandika P. Gunaretnam, Fudan Miao, Hesham Soliman, Bruce C. Carleton, Colin J. D. Ross

published 04 Nov 2022

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Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment

Sunil Thomas, Giancarlo Mercogliano, George C. Prendergast

published 02 Nov 2022

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Microglia have limited influence on early prion pathogenesis, clearance, or replication

Brent Race, Katie Williams, Chase Baune, James F. Striebel, Dan Long, Tina Thomas, Lori Lubke, Bruce Chesebro, James A. Carroll

published 27 Oct 2022

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The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells

Kozo Kagawa, Seidai Sato, Kazuya Koyama, Takeshi Imakura, Kojin Murakami, Yuya Yamashita, Nobuhito Naito, Hirohisa Ogawa, Hiroshi Kawano, Yasuhiko Nishioka

published 27 Oct 2022

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Variant APOL1 protein in plasma associates with larger particles in humans and mouse models of kidney injury

Michael Andrews, Teruhiko Yoshida, Clark M. Henderson, Hannah Pflaum, Ayako McGregor, Joshua A. Lieberman, Ian H. de Boer, Tomas Vaisar, Jonathan Himmelfarb, Bryan Kestenbaum, Joon-Yong Chung, Stephen M. Hewitt, Briana A. Santo, Brandon Ginley, Pinaki Sarder, Avi Z. Rosenberg, Taichi Murakami, Jeffrey B. Kopp, Zsuzsanna Kuklenyik, Andrew N. Hoofnagle

published 24 Oct 2022

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Role of Scl39a13/ZIP13 in cardiovascular homeostasis

Takafumi Hara, Ikuko Yamada, Takuto Ohashi, Masaru Tamura, Atsushi Hijikata, Takashi Watanabe, Minghao Gao, Kana Ito, Saeko Kawamata, Shiori Azuma, Emi Yoshigai, Yukiko Sumiyoshi, Natsumi Yasuhiro, Osamu Ohara, Heloísa G. dos Santos, Toshiyuki Fukada

published 21 Oct 2022

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Skin microbiota of oxazolone-induced contact hypersensitivity mouse model

Kuunsäde Mäenpää, Shuyuan Wang, Marit Ilves, Hani El-Nezami, Harri Alenius, Hanna Sinkko, Piia Karisola

published 20 Oct 2022

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‘Invisible actors’—How poor methodology reporting compromises mouse models of oncology: A cross-sectional survey

Elizabeth A. Nunamaker, Penny S. Reynolds

published 20 Oct 2022

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Evaluation of topical oclacitinib and nail trimming as a treatment for murine ulcerative dermatitis in laboratory mice

Steven E. Davison, Kathryn M. Emmer, Beatrice Ugiliweneza, Leslie C. Sherwood

published 18 Oct 2022

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Identification of suitable reference genes for normalization of reverse transcription quantitative real-time PCR (RT-qPCR) in the fibrotic phase of the bleomycin mouse model of pulmonary fibrosis

Oula Norman, Jarkko Koivunen, Joni M. Mäki, Taina Pihlajaniemi, Anne Heikkinen

published 17 Oct 2022

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Accumulation of senescence observed in spinocerebellar ataxia type 7 mouse model

William Miller, Charles Lewis Humphrey Pruett, William Stone, Cindy Eide, Megan Riddle, Courtney Popp, Matthew Yousefzadeh, Christopher Lees, Davis Seelig, Elizabeth Thompson, Harry Orr, Laura Niedernhofer, Jakub Tolar

published 17 Oct 2022

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Depletion of Scleraxis-lineage cells during tendon healing transiently impairs multi-scale restoration of tendon structure during early healing

Antonion Korcari, Samantha Muscat, Elizabeth McGinn, Mark R. Buckley, Alayna E. Loiselle

published 14 Oct 2022

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