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Mouse models

Ribitol dose-dependently enhances matriglycan expression and improves muscle function with prolonged life span in limb girdle muscular dystrophy 2I mouse model

Bo Wu, Morgan Drains, Sapana N. Shah, Pei Juan Lu, Victoria Leroy, Jessalyn Killilee, Raegan Rawls, Jason D. Tucker, Anthony Blaeser, Qi Long Lu

published 01 Dec 2022

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Maternal immune activation induces methylation changes in schizophrenia genes

Thomas Johnson, Defne Saatci, Lahiru Handunnetthi

published 30 Nov 2022

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Pax6 mutant cerebral organoids partially recapitulate phenotypes of Pax6 mutant mouse strains

Nurfarhana Ferdaos, Sally Lowell, John O. Mason

published 28 Nov 2022

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Monoallelic variants resulting in substitutions of MAB21L1 Arg51 Cause Aniridia and microphthalmia

Hildegard Nikki Hall, Hemant Bengani, Robert B. Hufnagel, Giuseppe Damante, Morad Ansari, Joseph A. Marsh, Graeme R. Grimes, Alex von Kriegsheim, David Moore, Lisa McKie, Jamalia Rahmat, Catia Mio, Moira Blyth, Wee Teik Keng, Lily Islam, Meriel McEntargart, Marcel M. Mannens, Veronica Van Heyningen, Joe Rainger, Brian P. Brooks, David R. FitzPatrick

published 22 Nov 2022

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Cysteinyl leukotriene receptor 1 is dispensable for osteoclast differentiation and bone resorption

Hirofumi Fujita, Aoi Ando, Yohei Mizusawa, Mitsuaki Ono, Takako Hattori, Munenori Habuta, Toshitaka Oohashi, Satoshi Kubota, Hideyo Ohuchi

published 17 Nov 2022

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Genetic ablation of metabotropic glutamate receptor 5 in rats results in an autism-like behavioral phenotype

Adrien A. Eshraghi, Idil Memis, Florence Wang, Isaiah White, Emily Furar, Jeenu Mittal, Moeed Moosa, Coleen M. Atkins, Rahul Mittal

published 16 Nov 2022

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Induced inactivation of Wnt16 in young adult mice has no impact on osteoarthritis development

Anna E. Törnqvist, Karin H. Nilsson, Lei Li, Claes Ohlsson, Sofia Movérare-Skrtic

published 11 Nov 2022

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Circulatory C-type natriuretic peptide reduces mucopolysaccharidosis-associated craniofacial hypoplasia in vivo

Marina Kashiwagi, Kazumasa Nakao, Shigeki Yamanaka, Ichiro Yamauchi, Takafumi Yamashita, Toshihito Fujii, Yohei Ueda, Mariko Yamamoto Kawai, Takuma Watanabe, Shizuko Fukuhara, Kazuhisa Bessho

published 10 Nov 2022

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Loss of GPR40 in LDL receptor-deficient mice exacerbates high-fat diet-induced hyperlipidemia and nonalcoholic steatohepatitis

Zhongyang Lu, Yanchun Li, Ai-Jun Li, Wing-Kin Syn, Stephen A. Wank, Maria F. Lopes-Virella, Yan Huang

published 04 Nov 2022

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All-trans retinoic acid (ATRA) regulates key genes in the RARG-TOP2B pathway and reduces anthracycline-induced cardiotoxicity

Jafar S. Hasbullah, Erika N. Scott, Amit P. Bhavsar, Erandika P. Gunaretnam, Fudan Miao, Hesham Soliman, Bruce C. Carleton, Colin J. D. Ross

published 04 Nov 2022

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Bin1 targeted immunotherapy alters the status of the enteric neurons and the microbiome during ulcerative colitis treatment

Sunil Thomas, Giancarlo Mercogliano, George C. Prendergast

published 02 Nov 2022

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Microglia have limited influence on early prion pathogenesis, clearance, or replication

Brent Race, Katie Williams, Chase Baune, James F. Striebel, Dan Long, Tina Thomas, Lori Lubke, Bruce Chesebro, James A. Carroll

published 27 Oct 2022

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The lymphocyte-specific protein tyrosine kinase-specific inhibitor A-770041 attenuates lung fibrosis via the suppression of TGF-β production in regulatory T-cells

Kozo Kagawa, Seidai Sato, Kazuya Koyama, Takeshi Imakura, Kojin Murakami, Yuya Yamashita, Nobuhito Naito, Hirohisa Ogawa, Hiroshi Kawano, Yasuhiko Nishioka

published 27 Oct 2022

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