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Mouse models

A novel model of gestational diabetes: Acute high fat high sugar diet results in insulin resistance and beta cell dysfunction during pregnancy in mice

Akansha Mishra, Simone Hernandez Ruano, Pradip K. Saha, Kathleen A. Pennington

published 15 Dec 2022

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Whole-body analysis of TRPML3 (MCOLN3) expression using a GFP-reporter mouse model reveals widespread expression in secretory cells and endocrine glands

Barbara Spix, Andrew J. Castiglioni, Natalie N. Remis, Emma N. Flores, Philipp Wartenberg, Amanda Wyatt, Ulrich Boehm, Thomas Gudermann, Martin Biel, Jaime García-Añoveros, Christian Grimm

published 15 Dec 2022

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Human CYP2B6 produces oxylipins from polyunsaturated fatty acids and reduces diet-induced obesity

Melissa M. Heintz, Jazmine A. Eccles, Emily M. Olack, Kristal M. Maner-Smith, Eric A. Ortlund, William S. Baldwin

published 15 Dec 2022

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Is the production of reactive oxygen and nitrogen species by macrophages associated with better infectious control in female mice with experimentally disseminated and pulmonary mucormycosis?

Amanda Ribeiro dos Santos, Thais Fernanda Fraga-Silva, Débora de Fátima Almeida-Donanzam, Angela Carolina Finatto, Camila Marchetti, Maria Izilda Andrade, Olavo Speranza de Arruda, Maria Sueli Parreira de Arruda, James Venturini

published 15 Dec 2022

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Aspirin mediates protection from diabetic kidney disease by inducing ferroptosis inhibition

Ziyu Wu, Dan Li, Dingyuan Tian, Xuejun Liu, Zhongming Wu

published 14 Dec 2022

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Age-dependent sex difference of non-alcoholic fatty liver disease in TSOD and db/db mice

Erdenetsogt Dungubat, Hiroyuki Kusano, Ichiro Mori, Hirosuke Tawara, Mitsuko Sutoh, Naoki Ohkura, Masakatsu Takanashi, Masahiko Kuroda, Naoki Harada, Emiko Udo, Masakazu Souda, Bungo Furusato, Toshio Fukusato, Yoshihisa Takahashi

published 14 Dec 2022

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Changes in adenosine receptors and neurotrophic factors in the SOD1^G93A mouse model of amyotrophic lateral sclerosis: Modulation by chronic caffeine

Nádia Rei, Cláudia A. Valente, Sandra H. Vaz, Miguel Farinha-Ferreira, Joaquim A. Ribeiro, Ana M. Sebastião

published 14 Dec 2022

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Differential transcriptomic changes in the central nervous system and urinary bladders of mice infected with a coronavirus

Taylor C. Clarkson, Nao Iguchi, Alison Xiaoqiao Xie, Anna P. Malykhina

published 09 Dec 2022

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Disseminated Intravascular Coagulation (DIC): Old player creates new perspectives on the polymicrobial sepsis model of CASP

Julia van der Linde, Stephan Diedrich, Thorben Klee, Claus-Dieter Heidecke, Stephan Kersting, Wolfram Keßler

published 08 Dec 2022

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Paroxetine treatment in an animal model of depression improves sperm quality

Reyhane Aghajani, Marziyeh Tavalaee, Niloofar Sadeghi, Mazdak Razi, Parviz Gharagozloo, Maryam Arbabian, Joël R. Drevet, Mohammad Hossein Nasr-Esfahani

published 08 Dec 2022

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A fusion protein comprising pneumococcal surface protein A and a pneumolysin derivate confers protection in a murine model of pneumococcal pneumonia

Tanila Wood dos Santos, Pedro Almeida Gonçalves, Dunia Rodriguez, José Aires Pereira, Carlos Augusto Real Martinez, Luciana C. C. Leite, Lucio F. C. Ferraz, Thiago Rojas Converso, Michelle Darrieux

published 07 Dec 2022

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AAV2/4-RS1 gene therapy in the retinoschisin knockout mouse model of X-linked retinoschisis

Brittni A. Scruggs, Sajag Bhattarai, Megan Helms, Ioana Cherascu, Adisa Salesevic, Elliot Stalter, Joseph Laird, Sheila A. Baker, Arlene V. Drack

published 07 Dec 2022

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Characterization of a KDM5 small molecule inhibitor with antiviral activity against hepatitis B virus

Sarah A. Gilmore, Danny Tam, Tara L. Cheung, Chelsea Snyder, Julie Farand, Ryan Dick, Mike Matles, Joy Y. Feng, Ricardo Ramirez, Li Li, Helen Yu, Yili Xu, Dwight Barnes, Gregg Czerwieniec, Katherine M. Brendza, Todd C. Appleby, Gabriel Birkus, Madeleine Willkom, Tetsuya Kobayashi, Eric Paoli, Marc Labelle, Thomas Boesen, Chin H. Tay, William E. Delaney IV, Gregory T. Notte, Uli Schmitz, Becket Feierbach

published 07 Dec 2022

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