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Mouse models

Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways

Zhenhe Zhang, Miles Freeman, Yiqiang Zhang, Danny El-Nachef, George Davenport, Allison Williams, W. Robb MacLellan

published 13 Feb 2023

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Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model

Yoshie Gon, Tsugumitsu Kandou, Tatsuaki Tsuruyama, Takeshi Iwasaki, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Shuji Akizuki, Akio Morinobu, Masaki Hikida, Tsuneyo Mimori, Hajime Yoshifuji

published 10 Feb 2023

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A generalized classification and coding system of Human Disease Animal Model Resource data with a case study to show improving database retrieval efficiency

Huiping Li, Wenjuan Zhang

published 09 Feb 2023

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Mutation of regulatory phosphorylation sites in PFKFB2 does not affect the anti-fibrotic effect of metformin in the kidney

Geoff Harley, Marina Katerelos, Kurt Gleich, Mardiana Lee, Peter F. Mount, David A. Power

published 09 Feb 2023

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The effects of microbiome-targeted therapy on cognitive impairment and postoperative cognitive dysfunction—A systematic review

Saiko Sugita, Peggy Tahir, Sakura Kinjo

published 07 Feb 2023

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Small molecule inhibiting microglial nitric oxide release could become a potential treatment for neuroinflammation

Philipp Jordan, Amanda Costa, Edgar Specker, Oliver Popp, Andrea Volkamer, Regina Piske, Tessa Obrusnik, Sabrina Kleissle, Kevin Stuke, Andre Rex, Martin Neuenschwander, Jens Peter von Kries, Marc Nazare, Phillip Mertins, Helmut Kettenmann, Susanne A. Wolf

published 06 Feb 2023

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Levofloxacin induces differential effects in the transcriptome between the gut, peripheral and axial joints in the Spondyloarthritis DBA/1 mice: Improvement of intestinal dysbiosis and the overall inflammatory process

Susana Aideé González-Chávez, Joan S. Salas-Leiva, Dayana E. Salas-Leiva, Salma Marcela López-Loeza, Jasanai Sausameda-García, Erasmo Orrantia-Borunda, Rubén Burgos-Vargas, Maria Fernanda Alvarado-Jáquez, Mayra Torres-Quintana, Rubén Cuevas-Martínez, Eduardo Chaparro-Barrera, Carlos Marín-Terrazas, Gerardo Pável Espino-Solís, José Pablo Romero-López, Brian de Jesús Bernal-Alferes, César Pacheco-Tena

published 02 Feb 2023

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High fat diet is protective against kidney injury in hypertensive-diabetic mice, but leads to liver injury

Véronique Cheff, Mayra Trentin-Sonoda, Amélie Blais, Jean-François Thibodeau, Chet E. Holterman, Alex Gutsol, Christopher R. J. Kennedy, Richard L. Hébert

published 02 Feb 2023

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Absorbed dose calculation for a realistic CT-derived mouse phantom irradiated with a standard Cs-137 cell irradiator using a Monte Carlo method

Amir Entezam, Andrew Fielding, David Bradley, Davide Fontanarosa

published 02 Feb 2023

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Robust performance of a live bacterial therapeutic chassis lacking the colibactin gene cluster

Aida Kalantari, Michael J. James, Lauren A. Renaud, Mylene Perreault, Catherine E. Monahan, Mary N. McDonald, David L. Hava, Vincent M. Isabella

published 02 Feb 2023

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Fast-onset effects of Pseudospondias microcarpa (A. Rich) Engl. (Anacardiaceae) hydroethanolic leaf extract on behavioral alterations induced by chronic mild stress in mice

Donatus Wewura Adongo, Priscilla Kolibea Mante, Kennedy Kwami Edem Kukuia, Charles Kwaku Benneh, Robert Peter Biney, Eric Boakye-Gyasi, Hilda Amekyeh, Benjamin Kingsley Harley, Augustine Tandoh, Prince Dagadu Okyere, Eric Woode

published 02 Feb 2023

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Identification of therapeutic sensitivities in a spheroid drug combination screen of Neurofibromatosis Type I associated High Grade Gliomas

Jacquelyn Dougherty, Kyra Harvey, Angela Liou, Katherine Labella, Deborah Moran, Stephanie Brosius, Thomas De Raedt

published 02 Feb 2023

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Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a^+/^- mouse model of Dravet syndrome

Lyndsey L. Anderson, Dilara A. Bahceci, Nicole A. Hawkins, Declan Everett-Morgan, Samuel D. Banister, Jennifer A. Kearney, Jonathon C. Arnold

published 26 Jan 2023

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