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Mouse models

Trp53 loss drives the neoplastic transformation of Pik3ca^H1047R-induced vascular malformation in a mouse model

Miaolu Tang, Jessica Sallavanti, Matthew Lanza, Danielle Covington, Wei Li

published 04 May 2026

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A digestive cartridge reduces intestinal injury in a murine model of necrotizing enterocolitis

Sarah Z. Wang, Djanira Fernandes, Savas T. Tsikis, Thomas I. Hirsch, Amy Pan, Mikayla Quigley, Valeria Ruiz, Scott C. Fligor, Carter R. Petty, Greta Loring, Stephen Davia, Juhye Kang, Mark Puder

published 30 Apr 2026

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Artemether ameliorates type 1 diabetic liver injury alongside the associated defects in mitochondrial ultrastructure and central carbon metabolism

Qike Fu, Jiaxin Li, Xiufen Gu, Yating Zhang, Pengxun Han, Xuewen Yu, Mumin Shao, Huili Sun, Yuchun Cai

published 29 Apr 2026

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Poldip2 deficiency attenuates lung disease severity in a mouse model of COVID-19

Ruinan Hu, Alejandra Valdivia, Taylor White, Willy Ju, Maegan L. Brockman, Zhan Zhang, Hongyan Qu, Georgette Gafford, Giji Joseph, Samantha Burton, Leda Bassit, Tysheena P. Charles, Raymond F. Schinazi, Rebecca D. Levit, Cynthia A. Derdeyn, Kathy K. Griendling, Bernard Lassègue, Marina S. Hernandes

published 29 Apr 2026

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ATRX function beyond hippocampal CA1 is required for cognitive deficits in mouse models of intellectual disability

Julia T. Brott, Nathalie G. Bérubé

published 28 Apr 2026

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Targeting pancreatic cancer with combined inhibition of EGFR and RAF

Jakob Brandstetter, Lea Goldstein, Tim Schreiber, Rupert Palme, Tobias Lindner, Markus Joksch, Bernd Krause, Brigitte Vollmar, Simone Kumstel

published 24 Apr 2026

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Reappraisal of profibrotic phenotype and cell-cycle state of renal tubular epithelium after ischemia–reperfusion injury

Daichi Fukaya, Wakako Kosakai, Tetsuya Sato, Tsutomu Inoue, Hiroaki Amano, Takeru Kusano, Hirokazu Okada

published 24 Apr 2026

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Targeted transferosomal delivery of cetirizine: A new approach to alopecia management

Noha Talal Zelai

published 24 Apr 2026

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In vivo mouse model of calcific myonecrosis induced by injury

Mai Kuratani, Sho Tsukamoto, Ryo Hamai, Kaori Tsuchiya, Osamu Suzuki, Taketo Yamada, Takenobu Katagiri

published 22 Apr 2026

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Comprehensive analysis of immune-related genes reveals diagnostic biomarkers and molecular subtypes in diabetic retinopathy

Lin Mu, Zhe Wang, Yaojiani Cao, Xuejun Wang, Xingtao Zhou

published 22 Apr 2026

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A flow cytometric assay of murine erythrocyte osmotic fragility

Pengwei Zhang, Lishuang Zhang, Shengbao Chen, Yanjuan Chen, Xianmin Zhu, Ruling Shen, Ying Lei

published 22 Apr 2026

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A kappa opioid receptor agonist, difelikefalin, improves acute kidney injury in experimental sepsis models

Yoshiharu Sawanobori, Daisuke Nakano, Hiroaki Kitamura, Kento Kitada, Takehiko Asaga, Norio Suzuki, Masayuki Yamamoto, Yuichi Ogino, Gotaro Shirakami, Akira Nishiyama

published 21 Apr 2026

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Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, Xuan Huang, Yupeng Li, Haolong Dong, Xianghua Xiong, Gang Liu, Qingyang Wang, Huipeng Chen

published 20 Apr 2026

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