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Mouse models

Effect of an NHE3 inhibitor in combination with an NPT2b inhibitor on gastrointestinal phosphate absorption in Rodent models

Xiaojun Wang, Xiaohong Yu, Kostas Gavardinas, Asim Dey, Hong Y. Zhang, Gina Porter, Leah Porras, Lan Yu, Haihong Guo, Charles A. Reidy, Joseph V. Haas, Yanping Xu, Mark C. Kowala, Prabhakar K. Jadhav, John R. Wetterau

published 26 Jan 2024

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Enhanced glucose utilization of skeletal muscle after 4 weeks of intermittent hypoxia in a mouse model of type 2 diabetes

Yuqi Zhao, Chaoqun Li, Shi Zhou, Youyu He, Yun Wang, Yuan Zhang, Li Wen

published 25 Jan 2024

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A phase 2 open-label study of the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy and pharmacology in mdx mice

Ian R. Woodcock, George Tachas, Nuket Desem, Peter J. Houweling, Michael Kean, Jaiman Emmanuel, Rachel Kennedy, Kate Carroll, Katy de Valle, Justine Adams, Shireen R. Lamandé, Chantal Coles, Chrystal Tiong, Matthew Burton, Daniella Villano, Peter Button, Jean-Yves Hogrel, Sarah Catling-Seyffer, Monique M. Ryan, Martin B. Delatycki, Eppie M. Yiu

published 25 Jan 2024

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Mice, rats, and guinea pigs differ in FMOs expression and tissue concentration of TMAO, a gut bacteria-derived biomarker of cardiovascular and metabolic diseases

Klaudia M. Maksymiuk, Mateusz Szudzik, Emilia Samborowska, Dawid Chabowski, Marek Konop, Marcin Ufnal

published 24 Jan 2024

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Ontology-based taxonomical analysis of experimentally verified natural and laboratory human coronavirus hosts and its implication for COVID-19 virus origination and transmission

Yang Wang, Muhui Ye, Fengwei Zhang, Zachary Thomas Freeman, Hong Yu, Xianwei Ye, Yongqun He

published 22 Jan 2024

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Large-scale gene expression changes in APP/PSEN1 and GFAP mutation models exhibit high congruence with Alzheimer’s disease

Stephen C. Gammie, Albee Messing, Mason A. Hill, Cynthia A. Kelm-Nelson, Tracy L. Hagemann

published 18 Jan 2024

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USP22 overexpression fails to augment tumor formation in MMTV-ERBB2 mice but loss of function impacts MMTV promoter activity

Xianghong Kuang, Andrew Salinger, Fernando Benavides, William J. Muller, Sharon Y. R. Dent, Evangelia Koutelou

published 18 Jan 2024

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Pathobiology of Candida auris infection analyzed by multiplexed imaging and single cell analysis

Chrystal Chadwick, Magdia De Jesus, Fiona Ginty, Jessica S. Martinez

published 17 Jan 2024

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Locomotor activity as an effective measure of the severity of inflammatory arthritis in a mouse model

Mélina R. Doucet, Angela M. Laevski, Jérémie A. Doiron, Luc H. Boudreau, Marc E. Surette

published 17 Jan 2024

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Longitudinal MRI and ¹H-MRS study of SCA7 mouse forebrain reveals progressive multiregional atrophy and early brain metabolite changes indicating early neuronal and glial dysfunction

Jean-Baptiste Pérot, Anna Niewiadomska-Cimicka, Emmanuel Brouillet, Yvon Trottier, Julien Flament

published 16 Jan 2024

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Acute seizure activity in neonatal inflammation-sensitized hypoxia-ischemia in mice

Angelina June, Weronika Matysik, Maria Marlicz, Emily Zucker, Pravin K. Wagley, Chia-Yi Kuan, Jennifer Burnsed

published 11 Jan 2024

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Ketogenic diet preserves muscle mass and strength in a mouse model of type 2 diabetes

Sol Been Park, Soo Jin Yang

published 10 Jan 2024

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Role of maraviroc and/or rapamycin in the liver of IL10 KO mice with frailty syndrome

Laura Pérez-Martínez, Lourdes Romero, Eva M. Verdugo-Sivianes, Sandra Muñoz-Galván, Susana Rubio-Mediavilla, Ana Amiama-Roig, Amancio Carnero, José-Ramón Blanco

published 10 Jan 2024

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