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Mouse models

Excitatory to inhibitory synaptic ratios are unchanged at presymptomatic stages in multiple models of ALS

Calum Bonthron, Sarah Burley, Matthew J. Broadhead, Vanya Metodieva, Seth G. N. Grant, Siddharthan Chandran, Gareth B. Miles

published 01 Aug 2024

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Environmental enrichment reduces restricted repetitive behavior by altering gray matter microstructure

Anna L. Farmer, Marcelo Febo, Bradley J. Wilkes, Mark H. Lewis

published 31 Jul 2024

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Anti-inflammatory effect of the combined treatment of LMT-28 and kaempferol in a collagen-induced arthritis mouse model

Young-Jin Jeong, Sun-Ae Park, Yeon-Hwa Park, Lee Kyung Kim, Hae-Ri Lee, Hee Jung Kim, Tae-Hwe Heo

published 31 Jul 2024

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Enhancing the solubility and potency of tetrahydrocurcumin as an anti-cancer agent using a β-cyclodextrin inclusion complex approach

Zhi Xuan Low, Michelle Yee Mun Teo, Fariza Juliana Nordin, Vijayaraj Kumar Palanirajan, Beata Morak-Młodawska, Asma Saleem Qazi, Lionel Lian Aun In

published 26 Jul 2024

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Botanical formulation HX110B ameliorates PPE-induced emphysema in mice via regulation of PPAR/RXR signaling pathway

Soojin Lee, Chang Hyung Lee, Jungkyu Lee, Yoonseon Jeong, Jong-Hyung Park, In-Jeong Nam, Doo Suk Lee, Hyun Myung Lee, Soo-Yeon Ahn, Eujung Kim, Seungyeon Jeong, Seung-Shin Yu, Wonwoo Lee

published 25 Jul 2024

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Benfotiamine protects MPTP-induced Parkinson’s disease mouse model via activating Nrf2 signaling pathway

Kai Wang, Chao Han, Jinwei Yang, Wenhao Xu, Lei Wang, Huaiyu Li, Yu Wang

published 23 Jul 2024

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Isoproterenol induced cardiac hypertrophy: A comparison of three doses and two delivery methods in C57BL/6J mice

Patricia Perez-Bonilla, Brianna LaViolette, Bidur Bhandary, Soumya Ullas, Xian Chen, Dinesh Hirenallur-Shanthappa

published 22 Jul 2024

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Remdesivir alleviates skin fibrosis by suppressing TGF-β1 signaling pathway

Jianwei Zhang, Xiujun Zhang, Xiaowei Guo, Wenqi Li, Tiantian Zhang, Dan Chai, Yuming Liu, Li Chen, Xiaoyu Ai, Tianyuan Zhou, Wenguo Wei, Xiaoting Gu, Xiaohe Li, Honggang Zhou

published 18 Jul 2024

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The differentiation of Lgr5+ progenitor cells on nanostructures of self-assembled silica beads

Wenjun Cai, Zhichun Huang, Baobin Sun, Ling Lu, Xiaoqiong Ding, Feng Tao

published 12 Jul 2024

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Preclinical studies of RA475, a guanidine-substituted spirocyclic candidate RPN13/ADRM1 inhibitor for treatment of ovarian cancer

Ravi K. Anchoori, Ssu-Hsueh Tseng, Hua-Ling Tsai, Vikrant Palande, Michelle A. Rudek, Richard B. S. Roden

published 11 Jul 2024

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Quercetin inhibits the epithelial-mesenchymal transition and reverses CDK4/6 inhibitor resistance in breast cancer by regulating circHIAT1/miR-19a-3p/CADM2 axis

Xiaogang Li, Chao Niu, Guoqiang Yi, Yuan Zhang, Wendi Jin, Zhiping Zhang, Wanfu Zhang, Bo Li

published 11 Jul 2024

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Dietary fiber induces a fat preference associated with the gut microbiota

Yi Jia Liow, Itsuka Kamimura, Masahiro Umezaki, Wataru Suda, Lena Takayasu

published 10 Jul 2024

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Diabetes mellitus, hearing loss, and therapeutic interventions: A systematic review of insights from preclinical animal models

Rahul Mittal, Grant Keith, Mitchel Lacey, Joana R. N. Lemos, Jeenu Mittal, Amro Assayed, Khemraj Hirani

published 10 Jul 2024

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