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Mouse models

Berberine potentiates liver inflammation and fibrosis in the PI*Z hAAT transgenic murine model

Yuanqing Lu, Naweed S. Mohammad, Jungnam Lee, Alek M. Aranyos, Karina A. Serban, Mark L. Brantly

published 19 Sep 2024

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Targeting ferroptosis with the lipoxygenase inhibitor PTC-041 as a therapeutic strategy for the treatment of Parkinson’s disease

Angela Minnella, Kevin P. McCusker, Akiko Amagata, Beatrice Trias, Marla Weetall, Joey C. Latham, Sloane O’Neill, Richard K. Wyse, Matthew B. Klein, Jeffrey K. Trimmer

published 18 Sep 2024

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Effects of HyaRegen gel on tumour proliferation of colorectal peritoneal metastases

Marie-Laure Perrin, Clément Bassetti, Sylvaine Durand Fontanier, Catherine Yardin, Sylvia M. Bardet, Abdelkader Taibi

published 10 Sep 2024

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β-Ionone enhances the inhibitory effects of 5-fluorouracil on the proliferation of gastric adenocarcinoma cells by the GSK-3β signaling pathway

Fa-lin Wang, Xiaoxia Chang, Yuanyang Shi, Tingting Yang, Juan Li, Hongwei Dong, Qi Wang, Shujun Zhang, Jiaren Liu

published 06 Sep 2024

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The time-dependent changes in a mouse model of traumatic brain injury with motor dysfunction

Dohee Kim, Jinsu Hwang, Jin Yoo, Jiyun Choi, Mahesh Ramalingam, Seongryul Kim, Hyong-Ho Cho, Byeong C. Kim, Han-Seong Jeong, Sujeong Jang

published 06 Sep 2024

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PIK-III exerts anti-fibrotic effects in activated fibroblasts by regulating p38 activation

Santiago Sanchez, Aaron K. McDowell-Sanchez, Sharaz B. Al-Meerani, Juan D. Cala-Garcia, Alan R. Waich Cohen, Scott A. Ochsner, Neil J. McKenna, Lindsay J. Celada, Minghua Wu, Shervin Assassi, Ivan O. Rosas, Konstantin Tsoyi

published 06 Sep 2024

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RETRACTED: Curcumin alleviates osteoarthritis in mice by suppressing osteoclastogenesis in subchondral bone via inhibiting NF-κB/JNK signaling pathway

Dong Ding, Guoqiang Liu, Jiangbo Yan, Qingyu Zhang, Fanding Meng, Limei Wang

published 05 Sep 2024

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A partial deletion within the meiosis-specific sporulation domain SPO22 of Tex11 is not associated with infertility in mice

Farah Ghieh, Bruno Passet, Elodie Poumerol, Johan Castille, Pierre Calvel, Jean-Luc Vilotte, Eli Sellem, Luc Jouneau, Hendrick Mambu-Mambueni, Henri-Jean Garchon, Eric Pailhoux, François Vialard, Béatrice Mandon-Pépin

published 04 Sep 2024

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Nesfatin-1 regulates the phenotype transition of cavernous smooth muscle cells by activating PI3K/AKT/mTOR signaling pathway to improve diabetic erectile dysfunction

Keming Chen, Bincheng Huang, Jiajing Feng, Zhengxing Hu, Shuzhe Fan, Shuai Ren, Haifu Tian, Al-qaisi Mohammed Abdulkarem M. M., Xuehao Wang, Yunshang Tuo, Xiaoxia Liang, Haibo Xie, Rui He, Guangyong Li

published 03 Sep 2024

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CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma

Lianyu Shan, Mojdeh Matloubi, Ifeoma Okwor, Sam Kung, Mohamed Sadek Almiski, Sujata Basu, Andrew Halayko, Latifa Koussih, Abdelilah S. Gounni

published 30 Aug 2024

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Upregulation of Metrnl improves diabetic kidney disease by inhibiting the TGF-β1/Smads signaling pathway: A potential therapeutic target

Lu Lin, Shulin Huang, Xin Lin, Xiaoling Liu, Xiangjin Xu, Chunmei Li, Pin Chen

published 27 Aug 2024

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Manufacturing CD20/CD19-targeted iCasp9 regulatable CAR-T_SCM cells using a Quantum pBac-based CAR-T engineering system

Peter S. Chang, Yi-Chun Chen, Wei-Kai Hua, Jeff C. Hsu, Jui-Cheng Tsai, Yi-Wun Huang, Yi-Hsin Kao, Pei-Hua Wu, Po-Nan Wang, Yi-Fang Chang, Ming-Chih Chang, Yu-Cheng Chang, Shiou-Ling Jian, Jiann-Shiun Lai, Ming-Tain Lai, Wei-Cheng Yang, Chia-Ning Shen, Kuo-Lan Karen Wen, Sareina Chiung-Yuan Wu

published 27 Aug 2024

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Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia

Junyi Xiong, Guojin Wu, Jinying Ning, Junlin Yan, Jian Yang, Jinsen Kang

published 22 Aug 2024

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