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Mouse models

Role of IL-23 signaling in the progression of premalignant oral lesions to cancer

Blaine Caughron, Yi Yang, M. Rita I. Young

published 17 Apr 2018

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Design and preclinical characterization of ALXN1210: A novel anti-C5 antibody with extended duration of action

Douglas Sheridan, Zhao-Xue Yu, Yuchun Zhang, Rekha Patel, Fang Sun, Melissa A. Lasaro, Keith Bouchard, Bruce Andrien, Andre Marozsan, Yi Wang, Paul Tamburini

published 12 Apr 2018

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Deletion of pro-angiogenic factor vasohibin-2 ameliorates glomerular alterations in a mouse diabetic nephropathy model

Kana Masuda, Katsuyuki Tanabe, Haruyo Ujike, Norikazu Hinamoto, Hiromasa Miyake, Satoshi Tanimura, Hitoshi Sugiyama, Yasufumi Sato, Yohei Maeshima, Jun Wada

published 11 Apr 2018

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DEC205-DC targeted DNA vaccine against CX3CR1 protects against atherogenesis in mice

Jimmy Jianheng Zhou, Yuan Min Wang, Vincent W. S. Lee, Geoff Yu Zhang, Heather Medbury, Helen Williams, Ya Wang, Thian Kui Tan, David C. H. Harris, Stephen I. Alexander, Anne M. Durkan

published 11 Apr 2018

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The flavonoid compound apigenin prevents colonic inflammation and motor dysfunctions associated with high fat diet-induced obesity

Daniela Gentile, Matteo Fornai, Rocchina Colucci, Carolina Pellegrini, Erika Tirotta, Laura Benvenuti, Cristina Segnani, Chiara Ippolito, Emiliano Duranti, Agostino Virdis, Sara Carpi, Paola Nieri, Zoltán H. Németh, Laura Pistelli, Nunzia Bernardini, Corrado Blandizzi, Luca Antonioli

published 11 Apr 2018

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XJB-5-131-mediated improvement in physiology and behaviour of the R6/2 mouse model of Huntington's disease is age- and sex- dependent

Aris A. Polyzos, Nigel I. Wood, Paul Williams, Peter Wipf, A. Jennifer Morton, Cynthia T. McMurray

published 09 Apr 2018

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Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

Xiaohai Wang, Karen Smith, Michelle Pearson, Anna Hughes, Mali L. Cosden, Jacob Marcus, J. Fred Hess, Mary J. Savage, Thomas Rosahl, Sean M. Smith, Joel B. Schachter, Jason M. Uslaner

published 06 Apr 2018

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Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL/6N mice

Sebastian E. Carrasco, Sishun Hu, Denise M. Imai, Ramesh Kumar, George E. Sandusky, X. Frank Yang, Wilbert A. Derbigny

published 06 Apr 2018

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Hypocomplementemia is associated with worse renal survival in ANCA-positive granulomatosis with polyangiitis and microscopic polyangiitis

Samuel Deshayes, Achille Aouba, Kathy Khoy, Delphine Mariotte, Thierry Lobbedez, Nicolas Martin Silva

published 05 Apr 2018

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Sildenafil ameliorates right ventricular early molecular derangement during left ventricular pressure overload

Yousuke Imai, Taro Kariya, Masaki Iwakiri, Yoshitsugu Yamada, Eiki Takimoto

published 05 Apr 2018

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Inositol 1,4,5-trisphosphate 3-kinase A overexpressed in mouse forebrain modulates synaptic transmission and mGluR-LTD of CA1 pyramidal neurons

Byungil Choi, Hyun Woo Lee, Seojung Mo, Jin Yong Kim, Hyun Wook Kim, Im Joo Rhyu, Eunhwa Hong, Yeon Kyung Lee, June-Seek Choi, Chong-Hyun Kim, Hyun Kim

published 04 Apr 2018

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Sequestration of synaptic proteins by alpha-synuclein aggregates leading to neurotoxicity is inhibited by small peptide

Mal-Gi Choi, Mi Jin Kim, Do-Geun Kim, Ri Yu, You-Na Jang, Won-Jong Oh

published 02 Apr 2018

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Novel monoclonal antibodies targeting the microtubule-binding domain of human tau

Cara L. Croft, Brenda D. Moore, Yong Ran, Paramita Chakrabarty, Yona Levites, Todd E. Golde, Benoit I. Giasson

published 02 Apr 2018

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