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Mouse models

Amelioration of Huntington's disease phenotypes by Beta-Lapachone is associated with increases in Sirt1 expression, CREB phosphorylation and PGC-1α deacetylation

Mijung Lee, Jae-Jun Ban, Jin-Young Chung, Wooseok Im, Manho Kim

published 09 May 2018

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Ciliary margin-derived BMP4 does not have a major role in ocular development

Rebecca L. Rausch, Richard T. Libby, Amy E. Kiernan

published 08 May 2018

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Defensive effect of microRNA-200b/c against amyloid-beta peptide-induced toxicity in Alzheimer's disease models

Sayuri Higaki, Masashi Muramatsu, Akio Matsuda, Kenji Matsumoto, Jun-ichi Satoh, Makoto Michikawa, Shumpei Niida

published 08 May 2018

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Renal papillary tip extract stimulates BNP production and excretion from cardiomyocytes

Itaru Goto, Ryuji Okamoto, Ryotaro Hashizume, Noboru Suzuki, Rie Ito, Keiichi Yamanaka, Hiromitsu Saito, Hiroshi Kiyonari, Isao Tawara, Yuki Kageyama, Yoshito Ogihara, Yusuf Ali, Norikazu Yamada, Naoyuki Katayama, Masaaki Ito

published 07 May 2018

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Recognition of early stage thigmotaxis in Morris water maze test with convolutional neural network

Akinori Higaki, Masaki Mogi, Jun Iwanami, Li-Juan Min, Hui-Yu Bai, Bao-Shuai Shan, Harumi Kan-no, Shuntaro Ikeda, Jitsuo Higaki, Masatsugu Horiuchi

published 03 May 2018

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Borrelia burgdorferi adhere to blood vessels in the dura mater and are associated with increased meningeal T cells during murine disseminated borreliosis

Ali Divan, Timothy Casselli, S. Anand Narayanan, Sanjib Mukherjee, David C. Zawieja, John A. Watt, Catherine A. Brissette, M. Karen Newell-Rogers

published 03 May 2018

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Inhibition of the H3K4 methyltransferase SET7/9 ameliorates peritoneal fibrosis

Ryo Tamura, Shigehiro Doi, Ayumu Nakashima, Kensuke Sasaki, Kazuya Maeda, Toshinori Ueno, Takao Masaki

published 03 May 2018

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Diet induced obesity alters muscle spindle afferent function in adult mice

Lubayna S. Elahi, Krystle N. Shamai, Adam M. Abtahie, Adam M. Cai, Shreejit Padmanabhan, Martina Bremer, Katherine A. Wilkinson

published 02 May 2018

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A multi-antigenic MVA vaccine increases efficacy of combination chemotherapy against Mycobacterium tuberculosis

Stéphane Leung-Theung-Long, Charles-Antoine Coupet, Marie Gouanvic, Doris Schmitt, Aurélie Ray, Chantal Hoffmann, Huguette Schultz, Sandeep Tyagi, Heena Soni, Paul J. Converse, Lilibeth Arias, Patricia Kleinpeter, Benoît Sansas, Khisimuzi Mdluli, Cristina Vilaplana, Pere-Joan Cardona, Eric Nuermberger, Jean-Baptiste Marchand, Nathalie Silvestre, Geneviève Inchauspé

published 02 May 2018

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Abrogation of transforming growth factor-β-induced tissue fibrosis in TBRI^caCol1a2Cre transgenic mice by the second generation tyrosine kinase inhibitor SKI-606 (Bosutinib)

Peter J. Wermuth, Sergio A. Jimenez

published 02 May 2018

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Mice lacking the transcriptional regulator Bhlhe40 have enhanced neuronal excitability and impaired synaptic plasticity in the hippocampus

Kelly A. Hamilton, Yue Wang, Sophia M. Raefsky, Sean Berkowitz, Ryan Spangler, Caitlin N. Suire, Simonetta Camandola, Robert H. Lipsky, Mark P. Mattson

published 01 May 2018

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Hedgehog inhibition mediates radiation sensitivity in mouse xenograft models of human esophageal adenocarcinoma

Jennifer Teichman, Lorin Dodbiba, Henry Thai, Andrew Fleet, Trevor Morey, Lucy Liu, Madison McGregor, Dangxiao Cheng, Zhuo Chen, Gail Darling, Yonathan Brhane, Yuyao Song, Osvaldo Espin-Garcia, Wei Xu, Hala Girgis, Joerg Schwock, Helen MacKay, Robert Bristow, Laurie Ailles, Geoffrey Liu

published 01 May 2018

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Comprehensive behavioral analysis of the Cdkl5 knockout mice revealed significant enhancement in anxiety- and fear-related behaviors and impairment in both acquisition and long-term retention of spatial reference memory

Kosuke Okuda, Keizo Takao, Aya Watanabe, Tsuyoshi Miyakawa, Masashi Mizuguchi, Teruyuki Tanaka

published 27 Apr 2018

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