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Mouse models

Using a non-surgical transcutaneous intraglandular injection technique to deliver cell and cell-free therapies to murine submandibular salivary glands

Arvind Hariharan, Janaki Iyer, Akram Almansoori, Younan Liu, Meet Shah, Piotr Pater, Tyler Lalonde, Simon D. Tran

published 10 Jul 2025

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Development of a novel PIK3CA-mutated pancreatic tumor mouse model and evaluation of the therapeutic effects of a PI3K inhibitor

Yoshimasa Suzuki, Makoto Sugimori, Yushi Kanemaru, Sho Onodera, Hiromi Tsuchiya, Aya Ikeda, Ryosuke Ikeda, Yoshihiro Goda, Hiroaki Kaneko, Kuniyasu Irie, Soichiro Sue, Hideaki Ijichi, Shin Maeda

published 10 Jul 2025

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Pain-stimulated ultrasound vocalizations and their impact on pain response in mice

Satoka Kasai, Saki Ukai, Junpei Kuroda, Tsugumi Yamauchi, Daisuke Yamada, Akiyoshi Saitoh, Satoshi Iriyama, Masashi Suzuki, Kazuki Arita, Yoshio Nakano, Satoru Miyazaki, Kazumi Yoshizawa

published 09 Jul 2025

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LINE-1 transposition into murine Thyroglobulin results in congenital thyroid dysplasia

Wendy J. Bailey, Bart M. G. Smits, Zoltan Erdos, John M. Gaspar, Pamela Lane, Sabu Kuruvilla, Thomas W. Rosahl, Douglas Thudium, Jingzhou Wang, Warren E. Glaab, Melissa MacGowan, Heather Multari, Christine Cumo, Adam Navis, Thomas Forest

published 08 Jul 2025

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Targeting interferon-stimulated gene of 20 kDa protein (Isg20) inhibits ribosome biogenesis to ameliorate the progression of renal fibrosis

Xiaoming Liu, Huijuan Wang, Kai Wang, Ying Liu

published 07 Jul 2025

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Semaglutide ameliorates diabetes-associated cognitive dysfunction in mouse model of type 2 diabetes

Yan Zhu, Yi He, Hongyan Yang, Yanbo Gao, Yan Wang, Peiqing Liu, Mengjuan Zhang

published 03 Jul 2025

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The effect of bone marrow mesenchymal stem cell-derived extracellular vesicles on bone mineral density and microstructure in osteoporosis: A systematic review and meta-analysis of preclinical studies

Ying Zhang, Xining Xu, Ximei Ren, Zhenghong Li

published 30 Jun 2025

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The effect of camel milk on house dust mite allergen induced asthma model in BALB/C mice

Ayaulym Rakhmatulina, Shynar Kenenbay, Altynay Abuova, Maigul Kizatova, Akniyet Ibraikhan, Farrukh Makhmudov, Aitugan Mukashev, Aigerim Aitbaeva, Zhastalap Abilkaiyr, Galiya Ibadullayeva, Urishbay Chomanov, Akhmet Murzabulatov, Sanavar Azimova, Altyn Kulpiisova, Svetlana Bayantassova, Nurbek Aralbayev, Nurbibi Imanbayeva, Fatima Dikhanbayeva, Nadezhda Burambayeva, Nazgul Smagulova, Arman Issimov, Peter White

published 27 Jun 2025

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Genome-wide landscape of miRNA-mRNA-lncRNA-circRNA ceRNA network in Nanos2 deficient mice

Hongyi Li, Yuan Li, Yuting Wang, Lijian Liu, Ji Cui, Mao Zhang, Yiming Yan

published 27 Jun 2025

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Nebulized and intravenous enzyme replacement therapy in mice with mucopolysaccharidosis type II

Alex J. Shamoun, Gisienne Reis, Malaica Ashley, Anatalia Labilloy, Leonardo F. Ferreira

published 26 Jun 2025

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Establishment of Cre/LoxP-mediated multifunctional reporter knock-in rats with the CRISPR system

Katsuyuki Nakamura, Sara Ito, Yoshihiro Ohguchi, Toshie Jimbo, Yusaku Wada, Ryota Nakajima, Masanobu Kanou, Kei Yamana, Hiroshi Ueda

published 25 Jun 2025

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Characterization of the Pank2^-/- mouse retinal phenotype as a pre-clinical model for pantothenate kinase-associated neurodegeneration

Grace Li-Na Su, Suh Young Jeong, Dahlia Wafai, Wayne Tschetter, Dolly Zhen, Susan J. Hayflick, Renee C. Ryals

published 24 Jun 2025

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Hederagenin’s uric acid-lowering effects in hyperuricemic mice: Mechanistic insights from molecular docking and in vivo analysis

Ping Chen, Ya-ni Tian, Jing-tao Wang, Xiang-lin Yin, Bao-sheng Guan, Xue Bai

published 24 Jun 2025

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