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Mouse models

A porcine model of Fanconi anemia

Brandon Hergert, Kristin M. Whitworth, Devorah C. Goldman, Lisa Moreau, Kelsey McQueen, Kalindi Parmar, Alan D’Andrea, Melissa S. Samuel, Kevin D. Wells, Randall S. Prather, Craig Dorell, Markus Grompe, William H. Fleming

published 31 Oct 2025

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Deletion of the scavenger receptor Scarb1 in osteoblast progenitors and myeloid cells does not affect bone mass

Michela Palmieri, Teenamol E. Joseph, Horacio Gomez-Acevedo, Ha-Neui Kim, Stavros C. Manolagas, Charles A. O’Brien, Elena Ambrogini

published 31 Oct 2025

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The combination of zalfermin and semaglutide has additive therapeutic effects in a diet-induced obese and biopsy-confirmed mouse model of MASH

Jenny Norlin, Maria Dermit, Nikos Sidiropoulos, Elisabeth D. Galsgaard, Henrik H. Hansen, Michael Feigh, Sanne S. Veidal, Markus Latta, Emma Henriksson, Birgitte Andersen

published 28 Oct 2025

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Auditory sensory processing induces cortical and thalamic event-related desynchronization in the mouse

Sarah H. McGill, Qilong Xin, Taruna Yadav, Charlie W. Zhao, Patrick Paszkowski, Fabrizio Darby, Mrinmoyee Guha, Tramy Nguyen, David S. Jin, Yuval Nir, Jiayang Liu, Lim-Anna Sieu, Hal Blumenfeld

published 27 Oct 2025

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Effects and mechanisms of engineered exosomes pretreated with Scutellaria baicalensis Georgi on osteoporosis

Chengbin Long, Xinhang Li, Yueshen Fan, Yingkun Hu, Wenge He, Ning Hu, Fang He

published 27 Oct 2025

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Luteolin alleviates CUMS-induced depressive-like behavioral deficits in mice through blocking the JAK2/STAT3 pathway

Hai-hong Wu, Shang-yue Chen, Dong-liang Yuan, Ting Zhao

published 24 Oct 2025

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Volumetric MRI of dorsal root ganglia as a biomarker for disease progression and response to AAV treatment in a mouse model of Fabry disease

Fuqiang Zhao, Shipeng Yuan, Charalambos Kaittanis, Mugdha Deshpande, Abirami Kugadas, Katayoun Derakhchan, Wanida Ruangsiriluk, Rizwana Islam, Natalia Boukharov, Paul McQuade, Johannes Tauscher, Christopher T. Winkelmann, Talakad G. Lohith

published 24 Oct 2025

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Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice

Daiki Kaito, Tomoyoshi Tamura, Sayuri Suzuki, Ryutaro Onishi, Kenji F. Tanaka, Jun Yoshino, Tadashi Matsuoka, Katsuya Maeshima, Junichi Sasaki, Koichiro Homma

published 21 Oct 2025

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Carbonizing technology enables Sanguisorbae Radix to inhibit yeast-to-hypha differentiation and biofilm formation in Candida albicans

Xuxi Cheng, Jinyun Song, Qinglian Hu, Hongdan Wu, Bohui Song, Ruixiao Ma, Jinghan Gao, Yiwei Wang, Huangjin Tong, Wei Gu, Hongyu Zhao

published 17 Oct 2025

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Partial removal of visceral epididymal white adipose tissue in obese Ldlr-/-.Leiden mice impacts adipokine secretion, plasma free fatty acids, and improves cerebrovascular health

Florine Seidel, Martine C. Morrison, Ilse Arnoldussen, Vivienne Verweij, Simon Ebert, Joline Attema, Christa de Ruiter, Wim van Duyvenvoorde, Jessica Snabel, Bram Geenen, Ayla Franco, Eveline Gart, Jürgen Bernhagen, Maximilian Wiesmann, Robert Kleemann, Amanda J. Kiliaan

published 17 Oct 2025

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Humanized monoacylglycerol acyltransferase 2 mice on a high-fat diet exhibit impaired liver detoxification during metabolic dysfunction-associated steatotic liver disease

J. Jose Corbalan, Pranavi Jagadeesan, Joseph T. Nickels Jr

published 15 Oct 2025

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Caveolin-1 knockout improves CFA-induced inflammatory pain in adult mice through modulating the cGAS STING pathway and autophagy

Huan Chang, Cancan Cheng, Ning Zheng, Haiyan Zhu, Hui Yang, Xiaocheng Zhu, Fan Zhang

published 09 Oct 2025

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Histopathological change of age-related hearing loss in female advance-aged CBA/CaJ mice

Yoshiaki Inuzuka, Kunio Mizutari, Takaomi Kurioka, Jun Suzuki, Yutaka Koizumi, Koji Araki, Akihiro Shiotani

published 07 Oct 2025

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