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Molecular development

Presenilin 2 Is the Predominant γ-Secretase in Microglia and Modulates Cytokine Release

Suman Jayadev, Amanda Case, Alison J. Eastman, Huy Nguyen, Julia Pollak, Jesse C. Wiley, Thomas Möller, Richard S. Morrison, Gwenn A. Garden

published 29 Dec 2010

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Oral Methylthioadenosine Administration Attenuates Fibrosis and Chronic Liver Disease Progression in Mdr2−/− Mice

M. Ujue Latasa, Carmen Gil-Puig, Maite G. Fernández-Barrena, Carlos M. Rodríguez-Ortigosa, Jesús M. Banales, Raquel Urtasun, Saioa Goñi, Miriam Méndez, Sara Arcelus, Nerea Juanarena, Juan A. Recio, Sophie Lotersztajn, Jesús Prieto, Carmen Berasain, Fernando J. Corrales, Jon Lecanda, Matías A. Ávila

published 29 Dec 2010

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Role of the Chemokine Receptors CCR1, CCR2 and CCR4 in the Pathogenesis of Experimental Dengue Infection in Mice

Rodrigo Guabiraba, Rafael Elias Marques, Anne-Gaëlle Besnard, Caio T. Fagundes, Danielle G. Souza, Bernhard Ryffel, Mauro M. Teixeira

published 29 Dec 2010

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Both Viremia and Cytokine Levels Associate with the Lack of Severe Disease in Secondary Dengue 1 Infection among Adult Chinese Patients

Yangbo Tang, Zhihua Kou, Fuchun Zhang, Xian Yao, Shengyong Liu, Jingming Ma, Yusen Zhou, Wei Zhao, Xiaoping Tang, Xia Jin

published 29 Dec 2010

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Intranasal Immunization with an Archaeal Lipid Mucosal Vaccine Adjuvant and Delivery Formulation Protects against a Respiratory Pathogen Challenge

Girishchandra B. Patel, Hongyan Zhou, Amalia Ponce, Greg Harris, Wangxue Chen

published 29 Dec 2010

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Role of Nitric Oxide in Shiga Toxin-2-Induced Premature Delivery of Dead Fetuses in Rats

Juliana Burdet, Elsa Zotta, Maximiliano Cella, Ana M. Franchi, Cristina Ibarra

published 29 Dec 2010

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T Cell LFA-1 Engagement Induces HuR-Dependent Cytokine mRNA Stabilization through a Vav-1, Rac1/2, p38MAPK and MKK3 Signaling Cascade

Vinod S. Ramgolam, Scott D. DeGregorio, Gautham K. Rao, Mark Collinge, Sharmila S. Subaran, Silva Markovic-Plese, Ruggero Pardi, Jeffrey R. Bender

published 29 Dec 2010

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Aldose Reductase Inhibition Prevents Metaplasia of Airway Epithelial Cells

Umesh C. S. Yadav, Leopoldo Aguilera-Aguirre, Kota V. Ramana, Istvan Boldogh, Satish K. Srivastava

published 28 Dec 2010

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Differential Effect of TLR2 and TLR4 on the Immune Response after Immunization with a Vaccine against Neisseria meningitidis or Bordetella pertussis

Floris Fransen, Rachel M. Stenger, Martien C. M. Poelen, Harry H. van Dijken, Betsy Kuipers, Claire J. P. Boog, Jos P. M. van Putten, Cécile A. C. M. van Els, Peter van der Ley

published 23 Dec 2010

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Bioinformatics Analysis of Macrophages Exposed to Porphyromonas gingivalis: Implications in Acute vs. Chronic Infections

Wen-Han Yu, Han Hu, Qingde Zhou, Yu Xia, Salomon Amar

published 23 Dec 2010

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PGE₂ Induces IL-6 in Orbital Fibroblasts through EP2 Receptors and Increased Gene Promoter Activity: Implications to Thyroid-Associated Ophthalmopathy

Nupur Raychaudhuri, Raymond S. Douglas, Terry J. Smith

published 23 Dec 2010

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Polyfunctional T-Cell Responses Are Disrupted by the Ovarian Cancer Ascites Environment and Only Partially Restored by Clinically Relevant Cytokines

Eric Tran, Julie S. Nielsen, Darin A. Wick, Alvin V. Ng, Lisa D. S. Johnson, Nancy J. Nesslinger, Elissa McMurtrie, John R. Webb, Brad H. Nelson

published 22 Dec 2010

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Trace Levels of Innate Immune Response Modulating Impurities (IIRMIs) Synergize to Break Tolerance to Therapeutic Proteins

Daniela Verthelyi, Vivian Wang

published 22 Dec 2010

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